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HOP2_ARATH
ID   HOP2_ARATH              Reviewed;         226 AA.
AC   Q9FX64;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Homologous-pairing protein 2 homolog;
DE   AltName: Full=Protein AHP2;
DE            Short=AtAHP2;
DE   AltName: Full=Protein ARABIDOPSIS HOMOLOG PAIRING 2;
DE   AltName: Full=Protein HOP2;
DE            Short=AtHOP2;
GN   Name=HOP2; Synonyms=AHP2; OrderedLocusNames=At1g13330; ORFNames=T6J4.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=12974806; DOI=10.1046/j.1365-313x.2003.01850.x;
RA   Schommer C., Beven A., Lawrenson T., Shaw P., Sablowski R.;
RT   "AHP2 is required for bivalent formation and for segregation of homologous
RT   chromosomes in Arabidopsis meiosis.";
RL   Plant J. 36:1-11(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Landsberg erecta; TISSUE=Flower bud;
RA   Siaud N., Doutriaux M.P.;
RT   "A study of the Arabidopsis Hop2 gene (AHP2).";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   INTERACTION WITH MND1.
RX   PubMed=16763194; DOI=10.1242/jcs.02967;
RA   Kerzendorfer C., Vignard J., Pedrosa-Harand A., Siwiec T., Akimcheva S.,
RA   Jolivet S., Sablowski R., Armstrong S., Schweizer D., Mercier R.,
RA   Schloegelhofer P.;
RT   "The Arabidopsis thaliana MND1 homologue plays a key role in meiotic
RT   homologous pairing, synapsis and recombination.";
RL   J. Cell Sci. 119:2486-2496(2006).
RN   [8]
RP   INTERACTION WITH MIP1.
RX   PubMed=19187040; DOI=10.1111/j.1365-313x.2009.03814.x;
RA   Dean P.J., Siwiec T., Waterworth W.M., Schloegelhofer P., Armstrong S.J.,
RA   West C.E.;
RT   "A novel ATM dependant X-ray inducible gene is essential for both plant
RT   meiosis and gametogenesis.";
RL   Plant J. 58:791-802(2009).
CC   -!- FUNCTION: Involved in bivalent formation and segregation of homologous
CC       chromosomes in meiosis.
CC   -!- SUBUNIT: Interacts with MND1 and MIP1. {ECO:0000269|PubMed:16763194,
CC       ECO:0000269|PubMed:19187040}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12974806}.
CC   -!- TISSUE SPECIFICITY: Expressed in vegetative and reproductive tissues.
CC       Found in seedlings, leaves and flowers. {ECO:0000269|PubMed:12974806}.
CC   -!- DISRUPTION PHENOTYPE: Sterility due to failure of both male and female
CC       gametophyte development. {ECO:0000269|PubMed:12974806}.
CC   -!- SIMILARITY: Belongs to the HOP2 family. {ECO:0000305}.
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DR   EMBL; AY225519; AAO67519.1; -; mRNA.
DR   EMBL; AJ627484; CAF28783.1; -; mRNA.
DR   EMBL; AC011810; AAG09555.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE29001.1; -; Genomic_DNA.
DR   EMBL; AK176610; BAD44373.1; -; mRNA.
DR   EMBL; AK227903; BAE99873.1; -; mRNA.
DR   EMBL; BT025172; ABE77410.1; -; mRNA.
DR   PIR; A86268; A86268.
DR   RefSeq; NP_172791.1; NM_101204.3.
DR   AlphaFoldDB; Q9FX64; -.
DR   SMR; Q9FX64; -.
DR   BioGRID; 23133; 1.
DR   IntAct; Q9FX64; 2.
DR   STRING; 3702.AT1G13330.1; -.
DR   PaxDb; Q9FX64; -.
DR   PRIDE; Q9FX64; -.
DR   ProteomicsDB; 230201; -.
DR   EnsemblPlants; AT1G13330.1; AT1G13330.1; AT1G13330.
DR   GeneID; 837893; -.
DR   Gramene; AT1G13330.1; AT1G13330.1; AT1G13330.
DR   KEGG; ath:AT1G13330; -.
DR   Araport; AT1G13330; -.
DR   TAIR; locus:2205359; AT1G13330.
DR   eggNOG; KOG4603; Eukaryota.
DR   HOGENOM; CLU_063266_0_0_1; -.
DR   InParanoid; Q9FX64; -.
DR   OMA; IETDEDC; -.
DR   OrthoDB; 1498024at2759; -.
DR   PhylomeDB; Q9FX64; -.
DR   PRO; PR:Q9FX64; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9FX64; baseline and differential.
DR   Genevisible; Q9FX64; AT.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IBA:GO_Central.
DR   GO; GO:0120231; C:DNA recombinase auxiliary factor complex; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0120230; F:recombinase activator activity; IBA:GO_Central.
DR   GO; GO:0051026; P:chiasma assembly; IMP:TAIR.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IBA:GO_Central.
DR   GO; GO:0000709; P:meiotic joint molecule formation; IBA:GO_Central.
DR   GO; GO:0010774; P:meiotic strand invasion involved in reciprocal meiotic recombination; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR040461; Hop2.
DR   InterPro; IPR010776; Hop2_WH_dom.
DR   InterPro; IPR040661; LZ3wCH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15938; PTHR15938; 1.
DR   Pfam; PF18517; LZ3wCH; 1.
DR   Pfam; PF07106; TBPIP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; DNA recombination; Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Homologous-pairing protein 2 homolog"
FT                   /id="PRO_0000378328"
FT   COILED          76..150
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  26245 MW;  4F8FB9166ABF294B CRC64;
     MAPKSDNTEA IVLNFVNEQN KPLNTQNAAD ALQKFNLKKT AVQKALDSLA DAGKITFKEY
     GKQKIYIARQ DQFEIPNSEE LAQMKEDNAK LQEQLQEKKK TISDVESEIK SLQSNLTLEE
     IQEKDAKLRK EVKEMEEKLV KLREGITLVR PEDKKAVEDM YADKINQWRK RKRMFRDIWD
     TVTENSPKDV KELKEELGIE YDEDVGLSFQ AYADLIQHGK KRPRGQ
 
 
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