ID   HOP2_DICDI              Reviewed;         243 AA.
AC   Q54UM1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Homologous-pairing protein 2 homolog;
GN   Name=hop2; ORFNames=DDB_G0280989;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for proper homologous pairing and efficient cross-
CC       over and intragenic recombination during meiosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HOP2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000040; EAL66791.1; -; Genomic_DNA.
DR   RefSeq; XP_640755.1; XM_635663.1.
DR   AlphaFoldDB; Q54UM1; -.
DR   SMR; Q54UM1; -.
DR   STRING; 44689.DDB0302478; -.
DR   PaxDb; Q54UM1; -.
DR   EnsemblProtists; EAL66791; EAL66791; DDB_G0280989.
DR   GeneID; 8622808; -.
DR   KEGG; ddi:DDB_G0280989; -.
DR   dictyBase; DDB_G0280989; hop2.
DR   eggNOG; KOG4603; Eukaryota.
DR   HOGENOM; CLU_063266_2_1_1; -.
DR   InParanoid; Q54UM1; -.
DR   OMA; KPFAIND; -.
DR   PhylomeDB; Q54UM1; -.
DR   PRO; PR:Q54UM1; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IBA:GO_Central.
DR   GO; GO:0120231; C:DNA recombinase auxiliary factor complex; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0120230; F:recombinase activator activity; IBA:GO_Central.
DR   GO; GO:0007129; P:homologous chromosome pairing at meiosis; IBA:GO_Central.
DR   GO; GO:0000709; P:meiotic joint molecule formation; IBA:GO_Central.
DR   GO; GO:0010774; P:meiotic strand invasion involved in reciprocal meiotic recombination; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR040461; Hop2.
DR   InterPro; IPR010776; Hop2_WH_dom.
DR   InterPro; IPR040661; LZ3wCH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR15938; PTHR15938; 1.
DR   Pfam; PF18517; LZ3wCH; 1.
DR   Pfam; PF07106; TBPIP; 1.
PE   3: Inferred from homology;
KW   Coiled coil; DNA recombination; DNA-binding; Meiosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..243
FT                   /note="Homologous-pairing protein 2 homolog"
FT                   /id="PRO_0000330899"
FT   REGION          217..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          86..153
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        220..235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   243 AA;  28510 MW;  04B23CE8D12EA282 CRC64;
     MSKKITKKDE VEENILNLIN KANRPYNYQM IEAAFPSMGK TQIVKTLKSL GEQGKLTFKE
     YNKAIIYWRI QDTGPKLDEQ GYEIPQESIH DLNRKLDGIN RQLEVEQDTL KSLISQSKQL
     NNQLSDEQIQ KEVNQLSTEN KELESKLLTF QTKEIMSDKD KQRLDDTIKK ARSEWVKRKA
     LFRDILDQVL ERSNKKKKDL QEDIGWETDE DLKIQMIPDY SKPLSQQTLS STNDESPFKK
     QKK