HOP2_SCHPO
ID HOP2_SCHPO Reviewed; 216 AA.
AC Q9HGK2;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Homologous-pairing protein 2;
DE AltName: Full=Meiotic expression up-regulated protein 13;
GN Name=meu13; Synonyms=hop2; ORFNames=SPAC222.15, SPAC821.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11447128; DOI=10.1093/emboj/20.14.3871;
RA Nabeshima K., Kakihara Y., Hiraoka Y., Nojima H.;
RT "A novel meiosis-specific protein of fission yeast, Meu13p, promotes
RT homologous pairing independently of homologous recombination.";
RL EMBO J. 20:3871-3881(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP INTERACTION WITH MCP7.
RX PubMed=15210864; DOI=10.1093/nar/gkh654;
RA Saito T.T., Tougan T., Kasama T., Okuzaki D., Nojima H.;
RT "Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates
RT with Meu13 and is required for meiotic recombination.";
RL Nucleic Acids Res. 32:3325-3339(2004).
CC -!- FUNCTION: Required for proper homologous pairing and efficient cross-
CC over and intragenic recombination during meiosis. Acts indirectly in a
CC process facilitating homologous recombination. Acts during mid- to
CC late-horse-tail period. {ECO:0000269|PubMed:11447128}.
CC -!- SUBUNIT: Interacts with mcp7. {ECO:0000269|PubMed:15210864}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11447128}.
CC -!- SIMILARITY: Belongs to the HOP2 family. {ECO:0000305}.
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DR EMBL; AB017038; BAB17055.1; -; Genomic_DNA.
DR EMBL; CU329670; CAD33796.1; -; Genomic_DNA.
DR RefSeq; NP_001018191.1; NM_001018551.1.
DR AlphaFoldDB; Q9HGK2; -.
DR SMR; Q9HGK2; -.
DR BioGRID; 280609; 22.
DR STRING; 4896.SPAC222.15.1; -.
DR PaxDb; Q9HGK2; -.
DR EnsemblFungi; SPAC222.15.1; SPAC222.15.1:pep; SPAC222.15.
DR GeneID; 3361533; -.
DR KEGG; spo:SPAC222.15; -.
DR PomBase; SPAC222.15; meu13.
DR VEuPathDB; FungiDB:SPAC222.15; -.
DR eggNOG; KOG4603; Eukaryota.
DR HOGENOM; CLU_063266_3_0_1; -.
DR InParanoid; Q9HGK2; -.
DR OMA; IETDEDC; -.
DR PhylomeDB; Q9HGK2; -.
DR PRO; PR:Q9HGK2; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0000794; C:condensed nuclear chromosome; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0120231; C:DNA recombinase auxiliary factor complex; IPI:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0120230; F:recombinase activator activity; IDA:PomBase.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:PomBase.
DR GO; GO:0000709; P:meiotic joint molecule formation; IDA:PomBase.
DR GO; GO:0010774; P:meiotic strand invasion involved in reciprocal meiotic recombination; IDA:PomBase.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR040461; Hop2.
DR InterPro; IPR010776; Hop2_WH_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR15938; PTHR15938; 1.
DR Pfam; PF07106; TBPIP; 1.
PE 1: Evidence at protein level;
KW DNA recombination; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..216
FT /note="Homologous-pairing protein 2"
FT /id="PRO_0000096447"
SQ SEQUENCE 216 AA; 24672 MW; E5A3839FAC13340A CRC64;
MAKAKEVKAK PIKGEEAEKL VYEYLRKTNR PYSATDVSAN LKNVVSKQVA QKALEQLRDT
GLIHGKLYGK QSVFVCLQDD LAAATPEELA EMEKQIQELK DEVSVVKTLY KEKCIELQAL
NNSLSPAEIR EKIQSIDKEI EETSSKLESL RNGTVKQISK EAMQKTDKNY DFAKKGFSNR
KKMFYDLWHL ITDSLENPKQ LWEKLGFETE GPIDLN
