ID   HOP2_XENLA              Reviewed;         214 AA.
AC   Q63ZL2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Homologous-pairing protein 2 homolog;
DE   AltName: Full=PSMC3-interacting protein;
DE   AltName: Full=Proteasome 26S ATPase subunit 3-interacting protein;
GN   Name=psmc3ip;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in meiotic recombination. Stimulates
CC       DMC1-mediated strand exchange required for pairing of homologous
CC       chromosomes during meiosis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HOP2 family. {ECO:0000305}.
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DR   EMBL; BC082900; AAH82900.1; -; mRNA.
DR   RefSeq; NP_001088086.1; NM_001094617.1.
DR   AlphaFoldDB; Q63ZL2; -.
DR   SMR; Q63ZL2; -.
DR   MaxQB; Q63ZL2; -.
DR   DNASU; 494783; -.
DR   GeneID; 494783; -.
DR   KEGG; xla:494783; -.
DR   CTD; 494783; -.
DR   Xenbase; XB-GENE-987673; psmc3ip.L.
DR   OrthoDB; 1498024at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 494783; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007131; P:reciprocal meiotic recombination; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR040461; Hop2.
DR   InterPro; IPR010776; Hop2_WH_dom.
DR   InterPro; IPR040661; LZ3wCH.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15938; PTHR15938; 1.
DR   Pfam; PF18517; LZ3wCH; 1.
DR   Pfam; PF07106; TBPIP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA recombination; Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..214
FT                   /note="Homologous-pairing protein 2 homolog"
FT                   /id="PRO_0000314138"
FT   REGION          115..179
FT                   /note="DNA-binding"
FT                   /evidence="ECO:0000250"
FT   COILED          79..147
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   214 AA;  24493 MW;  AF4FC051E22F1B73 CRC64;
     MSKSKEAAAS SIILKYLNDQ NRPYSTQDVF SNLQRDHGLG KTAVVKTMEL LAQKGKIKEK
     VYGKQKIYFA DQEQFPSVSD SELKDLDAQV TELSSKLQSS QQSCRQLESE LKDLTSSLTT
     EEMLKEVSCL KEECDRHEHK LTNIKSATNH VTPAEKEKVY GERKHFCKEW KKRKRMATDI
     FDAILEGYPK SKKQFFEEVG VETDEDCNVT VPDV