ID   HOP_BOVIN               Reviewed;          73 AA.
AC   Q8MJD5; Q3SZZ6;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Homeodomain-only protein;
DE   AltName: Full=Odd homeobox protein 1;
GN   Name=HOPX; Synonyms=HOD, HOP, OB1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RX   PubMed=14516659; DOI=10.1016/s0925-4773(03)00090-x;
RA   Adu J., Leong F.T., Smith N.R., Leek J.P., Markham A.F., Robinson P.A.,
RA   Mighell A.J.;
RT   "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain
RT   protein, during mouse development.";
RL   Mech. Dev. 119:S43-S47(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Atypical homeodomain protein which does not bind DNA and is
CC       required to modulate cardiac growth and development. Acts via its
CC       interaction with SRF, thereby modulating the expression of SRF-
CC       dependent cardiac-specific genes and cardiac development. Prevents SRF-
CC       dependent transcription either by inhibiting SRF binding to DNA or by
CC       recruiting histone deacetylase (HDAC) proteins that prevent
CC       transcription by SRF. Overexpression causes cardiac hypertrophy. Acts
CC       as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists
CC       in chaperone-mediated protein refolding. {ECO:0000250|UniProtKB:Q8R1H0,
CC       ECO:0000250|UniProtKB:Q9BPY8}.
CC   -!- SUBUNIT: Interacts with serum response factor (SRF). Component of a
CC       large complex containing histone deacetylases such as HDAC2. Interacts
CC       with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8.
CC       {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000250|UniProtKB:Q9BPY8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8R1H0}.
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DR   EMBL; AF492683; AAM46835.1; -; mRNA.
DR   EMBL; BC102635; AAI02636.1; -; mRNA.
DR   RefSeq; NP_776522.1; NM_174097.2.
DR   RefSeq; XP_005207997.1; XM_005207940.2.
DR   RefSeq; XP_005207998.1; XM_005207941.3.
DR   RefSeq; XP_005207999.1; XM_005207942.2.
DR   RefSeq; XP_005208000.1; XM_005207943.2.
DR   AlphaFoldDB; Q8MJD5; -.
DR   SMR; Q8MJD5; -.
DR   STRING; 9913.ENSBTAP00000003013; -.
DR   PaxDb; Q8MJD5; -.
DR   PRIDE; Q8MJD5; -.
DR   Ensembl; ENSBTAT00000003013; ENSBTAP00000003013; ENSBTAG00000002333.
DR   GeneID; 281270; -.
DR   KEGG; bta:281270; -.
DR   CTD; 84525; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002333; -.
DR   VGNC; VGNC:29907; HOPX.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00390000017143; -.
DR   HOGENOM; CLU_193231_0_0_1; -.
DR   InParanoid; Q8MJD5; -.
DR   OMA; EDSFKGC; -.
DR   OrthoDB; 1621268at2759; -.
DR   TreeFam; TF330730; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000002333; Expressed in thyroid gland and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0016575; P:histone deacetylation; IEA:Ensembl.
DR   GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:1903598; P:positive regulation of gap junction assembly; IEA:Ensembl.
DR   GO; GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IEA:Ensembl.
DR   GO; GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0043393; P:regulation of protein binding; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001829; P:trophectodermal cell differentiation; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR039162; HOPX.
DR   PANTHER; PTHR21408; PTHR21408; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Homeobox; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..73
FT                   /note="Homeodomain-only protein"
FT                   /id="PRO_0000049128"
FT   DNA_BIND        3..62
FT                   /note="Homeobox; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   73 AA;  8299 MW;  9214F86B3B58034E CRC64;
     MSTETASGPT EDQVEILEYN FNKVNKHPDP TTLCLIAAEA GLSEEETQKW FKQRLAQWRR
     SEGLPSECRS VTD