ID   HOP_CHICK               Reviewed;          73 AA.
AC   Q8JHU0;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Homeodomain-only protein;
DE   AltName: Full=Odd homeobox protein 1;
GN   Name=HOPX; Synonyms=HOD, HOP, OB1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14516659; DOI=10.1016/s0925-4773(03)00090-x;
RA   Adu J., Leong F.T., Smith N.R., Leek J.P., Markham A.F., Robinson P.A.,
RA   Mighell A.J.;
RT   "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain
RT   protein, during mouse development.";
RL   Mech. Dev. 119:S43-S47(2002).
CC   -!- FUNCTION: Atypical homeodomain protein which does not bind DNA and is
CC       required to modulate cardiac growth and development. May act via an
CC       interaction with SRF, leading to modulate the expression of SRF-
CC       dependent cardiac-specific genes and cardiac development. May act as a
CC       co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in
CC       chaperone-mediated protein refolding. {ECO:0000250|UniProtKB:Q8R1H0,
CC       ECO:0000250|UniProtKB:Q9BPY8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8R1H0}.
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DR   EMBL; AF492684; AAM46836.1; -; mRNA.
DR   RefSeq; NP_989887.1; NM_204556.1.
DR   RefSeq; XP_015131592.1; XM_015276106.1.
DR   RefSeq; XP_015131593.1; XM_015276107.1.
DR   RefSeq; XP_015131594.1; XM_015276108.1.
DR   RefSeq; XP_015131595.1; XM_015276109.1.
DR   AlphaFoldDB; Q8JHU0; -.
DR   SMR; Q8JHU0; -.
DR   STRING; 9031.ENSGALP00000037156; -.
DR   PaxDb; Q8JHU0; -.
DR   Ensembl; ENSGALT00000037951; ENSGALP00000037156; ENSGALG00000011404.
DR   GeneID; 395241; -.
DR   KEGG; gga:395241; -.
DR   CTD; 84525; -.
DR   VEuPathDB; HostDB:geneid_395241; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00390000017143; -.
DR   HOGENOM; CLU_193231_0_0_1; -.
DR   InParanoid; Q8JHU0; -.
DR   OMA; EDSFKGC; -.
DR   OrthoDB; 1621268at2759; -.
DR   PhylomeDB; Q8JHU0; -.
DR   TreeFam; TF330730; -.
DR   PRO; PR:Q8JHU0; -.
DR   Proteomes; UP000000539; Chromosome 4.
DR   Bgee; ENSGALG00000011404; Expressed in granulocyte and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0051131; P:chaperone-mediated protein complex assembly; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0016575; P:histone deacetylation; IEA:Ensembl.
DR   GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:1903598; P:positive regulation of gap junction assembly; IEA:Ensembl.
DR   GO; GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IEA:Ensembl.
DR   GO; GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Ensembl.
DR   GO; GO:0008016; P:regulation of heart contraction; IEA:Ensembl.
DR   GO; GO:0043393; P:regulation of protein binding; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR039162; HOPX.
DR   PANTHER; PTHR21408; PTHR21408; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Homeobox; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..73
FT                   /note="Homeodomain-only protein"
FT                   /id="PRO_0000049133"
FT   DNA_BIND        3..62
FT                   /note="Homeobox; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   73 AA;  8342 MW;  441B97093E23B466 CRC64;
     MATEKSVTPT EEQLEILEYN FCKVNKHPDP TTLCLIAAET GLSEEQTLKW FKQRLAEWRK
     SEGLPSECGS VRD