ID   HOP_DANRE               Reviewed;          77 AA.
AC   Q8AYB8; A8E5B8; Q4V9K4;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Homeodomain-only protein;
GN   Name=hopx; Synonyms=hop;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=12297045; DOI=10.1016/s0092-8674(02)00932-7;
RA   Chen F., Kook H., Milewski R., Gitler A.D., Lu M.M., Li J., Nazarian R.,
RA   Schnepp R., Jen K., Biben C., Runke G., Mackay J.P., Novotny J.,
RA   Schwartz R.J., Harvey R.P., Mullins M.C., Epstein J.A.;
RT   "Hop is an unusual homeobox gene that modulates cardiac development.";
RL   Cell 110:713-723(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=WIK; TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Atypical homeodomain protein which does not bind DNA and is
CC       required to modulate cardiac growth and development. May act via an
CC       interaction with SRF, leading to modulate the expression of SRF-
CC       dependent cardiac-specific genes and cardiac development
CC       (PubMed:12297045). May act as a co-chaperone for HSPA1A and HSPA1B
CC       chaperone proteins and assist in chaperone-mediated protein refolding
CC       (By similarity). {ECO:0000250|UniProtKB:Q9BPY8,
CC       ECO:0000269|PubMed:12297045}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8R1H0}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF536198; AAN16321.1; -; mRNA.
DR   EMBL; BC096856; AAH96856.1; -; mRNA.
DR   EMBL; BC153537; AAI53538.1; -; mRNA.
DR   RefSeq; NP_937852.1; NM_198209.2.
DR   AlphaFoldDB; Q8AYB8; -.
DR   SMR; Q8AYB8; -.
DR   STRING; 7955.ENSDARP00000112208; -.
DR   PaxDb; Q8AYB8; -.
DR   Ensembl; ENSDART00000125203; ENSDARP00000112208; ENSDARG00000089368.
DR   Ensembl; ENSDART00000193575; ENSDARP00000156504; ENSDARG00000089368.
DR   GeneID; 386589; -.
DR   KEGG; dre:386589; -.
DR   CTD; 84525; -.
DR   ZFIN; ZDB-GENE-031016-2; hopx.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00390000017143; -.
DR   HOGENOM; CLU_193231_0_0_1; -.
DR   InParanoid; Q8AYB8; -.
DR   OMA; EDSFKGC; -.
DR   OrthoDB; 1621268at2759; -.
DR   PhylomeDB; Q8AYB8; -.
DR   TreeFam; TF330730; -.
DR   PRO; PR:Q8AYB8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000089368; Expressed in pharyngeal gill and 27 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR039162; HOPX.
DR   PANTHER; PTHR21408; PTHR21408; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Homeobox; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..77
FT                   /note="Homeodomain-only protein"
FT                   /id="PRO_0000049134"
FT   DNA_BIND        7..65
FT                   /note="Homeobox; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   77 AA;  8519 MW;  230DAD578E93AB33 CRC64;
     MSANGNAALG VRLTEDQVKV LEENFTKVSK HPDETTLMLI AAECGLSEEQ TAVWFRMRNA
     QWRKAEGLPA ELGSVKD