ID   HOP_PIG                 Reviewed;          73 AA.
AC   Q8MJD6;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Homeodomain-only protein;
DE   AltName: Full=Odd homeobox protein 1;
GN   Name=HOPX; Synonyms=HOD, HOP, OB1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14516659; DOI=10.1016/s0925-4773(03)00090-x;
RA   Adu J., Leong F.T., Smith N.R., Leek J.P., Markham A.F., Robinson P.A.,
RA   Mighell A.J.;
RT   "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain
RT   protein, during mouse development.";
RL   Mech. Dev. 119:S43-S47(2002).
CC   -!- FUNCTION: Atypical homeodomain protein which does not bind DNA and is
CC       required to modulate cardiac growth and development. Acts via its
CC       interaction with SRF, thereby modulating the expression of SRF-
CC       dependent cardiac-specific genes and cardiac development. Prevents SRF-
CC       dependent transcription either by inhibiting SRF binding to DNA or by
CC       recruiting histone deacetylase (HDAC) proteins that prevent
CC       transcription by SRF. Overexpression causes cardiac hypertrophy. Acts
CC       as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists
CC       in chaperone-mediated protein refolding. {ECO:0000250|UniProtKB:Q8R1H0,
CC       ECO:0000250|UniProtKB:Q9BPY8}.
CC   -!- SUBUNIT: Interacts with serum response factor (SRF). Component of a
CC       large complex containing histone deacetylases such as HDAC2. Interacts
CC       with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8.
CC       {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000250|UniProtKB:Q9BPY8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8R1H0}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8R1H0}.
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DR   EMBL; AF492682; AAM46834.1; -; mRNA.
DR   RefSeq; NP_998957.1; NM_213792.2.
DR   RefSeq; XP_005666739.1; XM_005666682.2.
DR   RefSeq; XP_005666740.1; XM_005666683.2.
DR   RefSeq; XP_005666741.1; XM_005666684.2.
DR   RefSeq; XP_005666743.1; XM_005666686.2.
DR   RefSeq; XP_005666744.1; XM_005666687.1.
DR   RefSeq; XP_005666746.1; XM_005666689.1.
DR   AlphaFoldDB; Q8MJD6; -.
DR   SMR; Q8MJD6; -.
DR   STRING; 9823.ENSSSCP00000009489; -.
DR   PaxDb; Q8MJD6; -.
DR   PeptideAtlas; Q8MJD6; -.
DR   Ensembl; ENSSSCT00000063895; ENSSSCP00000032389; ENSSSCG00000008898.
DR   Ensembl; ENSSSCT00015054677; ENSSSCP00015021918; ENSSSCG00015040422.
DR   Ensembl; ENSSSCT00025005288; ENSSSCP00025002042; ENSSSCG00025003964.
DR   Ensembl; ENSSSCT00030085485; ENSSSCP00030039392; ENSSSCG00030061052.
DR   Ensembl; ENSSSCT00035027848; ENSSSCP00035010685; ENSSSCG00035021340.
DR   Ensembl; ENSSSCT00040026935; ENSSSCP00040011380; ENSSSCG00040019857.
DR   Ensembl; ENSSSCT00045029951; ENSSSCP00045020761; ENSSSCG00045017533.
DR   Ensembl; ENSSSCT00050056064; ENSSSCP00050023808; ENSSSCG00050041351.
DR   Ensembl; ENSSSCT00055039446; ENSSSCP00055031377; ENSSSCG00055020064.
DR   Ensembl; ENSSSCT00060090539; ENSSSCP00060039180; ENSSSCG00060066167.
DR   Ensembl; ENSSSCT00065048838; ENSSSCP00065021107; ENSSSCG00065035819.
DR   Ensembl; ENSSSCT00070023279; ENSSSCP00070019254; ENSSSCG00070011936.
DR   Ensembl; ENSSSCT00070023313; ENSSSCP00070019282; ENSSSCG00070011936.
DR   GeneID; 396692; -.
DR   KEGG; ssc:396692; -.
DR   CTD; 84525; -.
DR   VGNC; VGNC:88932; HOPX.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00390000017143; -.
DR   HOGENOM; CLU_193231_0_0_1; -.
DR   InParanoid; Q8MJD6; -.
DR   TreeFam; TF330730; -.
DR   Proteomes; UP000008227; Chromosome 8.
DR   Proteomes; UP000314985; Chromosome 8.
DR   Bgee; ENSSSCG00000008898; Expressed in lung and 43 other tissues.
DR   ExpressionAtlas; Q8MJD6; baseline and differential.
DR   Genevisible; Q8MJD6; SS.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR039162; HOPX.
DR   PANTHER; PTHR21408; PTHR21408; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Developmental protein; Homeobox; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..73
FT                   /note="Homeodomain-only protein"
FT                   /id="PRO_0000049131"
FT   DNA_BIND        3..62
FT                   /note="Homeobox; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   73 AA;  8320 MW;  DFA6307BCD8F3ECA CRC64;
     MSAEPANGPT EDQVEILEYN FNKVNRHPDP TTLCLIAAEA GLSEEETQKW FKQRLAQWRR
     SEGLPSECRS VTD