HOP_RAT
ID HOP_RAT Reviewed; 73 AA.
AC Q78ZR5; Q8R4G4;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Homeodomain-only protein;
DE AltName: Full=Global ischemia-induced gene 15B protein;
DE Short=GIIg15b;
DE AltName: Full=Odd homeobox protein 1;
GN Name=Hopx; Synonyms=Giig15b, Hod, Hop, Ob1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14516659; DOI=10.1016/s0925-4773(03)00090-x;
RA Adu J., Leong F.T., Smith N.R., Leek J.P., Markham A.F., Robinson P.A.,
RA Mighell A.J.;
RT "Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain
RT protein, during mouse development.";
RL Mech. Dev. 119:S43-S47(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Jin K., Chen J., Graham S.H., Simon R.P.;
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=12297046; DOI=10.1016/s0092-8674(02)00933-9;
RA Shin C.H., Liu Z.-P., Passier R., Zhang C.-L., Wang D.-Z., Harris T.M.,
RA Yamagishi H., Richardson J.A., Childs G., Olson E.N.;
RT "Modulation of cardiac growth and development by HOP, an unusual
RT homeodomain protein.";
RL Cell 110:725-735(2002).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Atypical homeodomain protein which does not bind DNA and is
CC required to modulate cardiac growth and development. Acts via its
CC interaction with SRF, thereby modulating the expression of SRF-
CC dependent cardiac-specific genes and cardiac development. Prevents SRF-
CC dependent transcription either by inhibiting SRF binding to DNA or by
CC recruiting histone deacetylase (HDAC) proteins that prevent
CC transcription by SRF. Overexpression causes cardiac hypertrophy. Acts
CC as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists
CC in chaperone-mediated protein refolding. {ECO:0000250|UniProtKB:Q8R1H0,
CC ECO:0000250|UniProtKB:Q9BPY8}.
CC -!- SUBUNIT: Interacts with serum response factor (SRF). Component of a
CC large complex containing histone deacetylases such as HDAC2. Interacts
CC with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8.
CC {ECO:0000250|UniProtKB:Q8R1H0, ECO:0000250|UniProtKB:Q9BPY8}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12297046}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF492685; AAM46837.1; -; mRNA.
DR EMBL; AF474162; AAL85327.1; -; mRNA.
DR EMBL; BC070950; AAH70950.1; -; mRNA.
DR RefSeq; NP_598305.2; NM_133621.2.
DR AlphaFoldDB; Q78ZR5; -.
DR BMRB; Q78ZR5; -.
DR SMR; Q78ZR5; -.
DR STRING; 10116.ENSRNOP00000044357; -.
DR PaxDb; Q78ZR5; -.
DR PRIDE; Q78ZR5; -.
DR GeneID; 171160; -.
DR KEGG; rno:171160; -.
DR UCSC; RGD:621841; rat.
DR CTD; 84525; -.
DR RGD; 621841; Hopx.
DR VEuPathDB; HostDB:ENSRNOG00000024689; -.
DR eggNOG; KOG0490; Eukaryota.
DR HOGENOM; CLU_193231_0_0_1; -.
DR InParanoid; Q78ZR5; -.
DR OMA; EDSFKGC; -.
DR OrthoDB; 1621268at2759; -.
DR PhylomeDB; Q78ZR5; -.
DR TreeFam; TF330730; -.
DR PRO; PR:Q78ZR5; -.
DR Proteomes; UP000002494; Chromosome 14.
DR Bgee; ENSRNOG00000024689; Expressed in esophagus and 20 other tissues.
DR Genevisible; Q78ZR5; RN.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051131; P:chaperone-mediated protein complex assembly; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0016575; P:histone deacetylation; ISO:RGD.
DR GO; GO:0048286; P:lung alveolus development; ISO:RGD.
DR GO; GO:0045596; P:negative regulation of cell differentiation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:1903598; P:positive regulation of gap junction assembly; ISO:RGD.
DR GO; GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; ISO:RGD.
DR GO; GO:0051155; P:positive regulation of striated muscle cell differentiation; ISO:RGD.
DR GO; GO:0008016; P:regulation of heart contraction; ISO:RGD.
DR GO; GO:0043393; P:regulation of protein binding; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001829; P:trophectodermal cell differentiation; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR039162; HOPX.
DR PANTHER; PTHR21408; PTHR21408; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Homeobox; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..73
FT /note="Homeodomain-only protein"
FT /id="PRO_0000049132"
FT DNA_BIND 3..62
FT /note="Homeobox; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT CONFLICT 6
FT /note="A -> G (in Ref. 2; AAL85327)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 73 AA; 8282 MW; 9D9B6D7F7A11C592 CRC64;
MSAQTASGPT EDQVEILEYN FNKVNKHPDP TTLCLIAAEA GLTEEQTQKW FKQRLAEWRR
SEGLPSECRS VTD
