HORM1_BOVIN
ID HORM1_BOVIN Reviewed; 393 AA.
AC Q2KIY6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=HORMA domain-containing protein 1;
GN Name=HORMAD1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a key role in meiotic progression. Regulates 3
CC different functions during meiosis: ensures that sufficient numbers of
CC processed DNA double-strand breaks (DSBs) are available for successful
CC homology search by increasing the steady-state numbers of single-
CC stranded DSB ends. Promotes synaptonemal-complex formation
CC independently of its role in homology search. Plays a key role in the
CC male mid-pachytene checkpoint and the female meiotic prophase
CC checkpoint: required for efficient build-up of ATR activity on
CC unsynapsed chromosome regions, a process believed to form the basis of
CC meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase
CC quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SUBUNIT: Interacts with HORMAD2. Interacts with IHO1.
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}.
CC Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially
CC localizes to unsynapsed or desynapsed chromosomal regions during the
CC prophase I stage of meiosis. TRIP13 is required for depletion from
CC synapsed chromosomes. The expression of the phosphorylated form at Ser-
CC 376 is restricted to unsynapsed chromosomal regions (By similarity).
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- PTM: Phosphorylated at Ser-376 in a SPO11-dependent manner.
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI12461.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFC03030055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112460; AAI12461.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001039770.2; NM_001046305.2.
DR AlphaFoldDB; Q2KIY6; -.
DR SMR; Q2KIY6; -.
DR STRING; 9913.ENSBTAP00000003529; -.
DR PaxDb; Q2KIY6; -.
DR PRIDE; Q2KIY6; -.
DR Ensembl; ENSBTAT00000003529; ENSBTAP00000003529; ENSBTAG00000002724.
DR Ensembl; ENSBTAT00000003530; ENSBTAP00000003530; ENSBTAG00000002724.
DR GeneID; 529615; -.
DR KEGG; bta:529615; -.
DR CTD; 84072; -.
DR VEuPathDB; HostDB:ENSBTAG00000002724; -.
DR VGNC; VGNC:55235; HORMAD1.
DR eggNOG; KOG4652; Eukaryota.
DR GeneTree; ENSGT00390000018130; -.
DR HOGENOM; CLU_058638_1_0_1; -.
DR InParanoid; Q2KIY6; -.
DR OMA; GNCEGVI; -.
DR OrthoDB; 1038689at2759; -.
DR TreeFam; TF313989; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000002724; Expressed in spermatid and 42 other tissues.
DR ExpressionAtlas; Q2KIY6; baseline.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR GO; GO:0001824; P:blastocyst development; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0042138; P:meiotic DNA double-strand break formation; ISS:UniProtKB.
DR GO; GO:0051598; P:meiotic recombination checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0051177; P:meiotic sister chromatid cohesion; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR GO; GO:0060629; P:regulation of homologous chromosome segregation; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; SSF56019; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Differentiation; Meiosis; Nucleus; Oogenesis; Phosphoprotein;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..393
FT /note="HORMA domain-containing protein 1"
FT /id="PRO_0000410911"
FT DOMAIN 24..226
FT /note="HORMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT REGION 322..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 382..385
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 334..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 375
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D5T7"
FT CONFLICT 62
FT /note="C -> S (in Ref. 2; AAI12461)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 393 AA; 44785 MW; FE951321CE6CD2B1 CRC64;
MATAQLQRTS MSALIFPNKI STEQQSLVLV KRLLAVSVSC ITYLRGIFPE CAYGTRYLDD
LCVKILREDK NCPGSTQLVK WMLGCYDALH KKYLRMVVLA VYTNPEDPQT ISECYQFKFK
YTSNGPVMDF TSKNQSNEPN MSSADTKKAS ILLIRKIYIL MQNLGPLPND VCLTMKLFYY
DEVTPPDYQP PGFKDGDCEG VIFEGEPMYL NVGEVPTPFH TFKVKVTTER ERMENIGSGI
LSPKQLKTPL QKILTDKDDL EDDQEHYISD EFDTETKMEE QEKNPGCSVR REAGFICEED
EMKSKGSPDF SISHSQVEQL VSKTSELDVS ESKTRSGKIF QNKMANGNQQ VKSKENRKRT
QLESGKTVLH PFDSSSQESV PKRRKFSEPK ERI
