ID   HORM1_DANRE             Reviewed;         356 AA.
AC   A2BF66; Q6DHR9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=HORMA domain-containing protein 1;
GN   Name=hormad1; ORFNames=si:dkey-30o16.5, zgc:92129;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in meiotic progression by ensuring that
CC       sufficient numbers of processed DNA double-strand breaks (DSBs) are
CC       available for successful homology search, promoting synaptonemal-
CC       complex formation independently and playing key role in the male mid-
CC       pachytene checkpoint and the female meiotic prophase checkpoint.
CC       {ECO:0000250|UniProtKB:Q9D5T7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially
CC       localizes to unsynapsed or desynapsed chromosomal regions during the
CC       prophase I stage of meiosis. {ECO:0000250|UniProtKB:Q9D5T7}.
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DR   EMBL; BX248517; CAM12962.1; -; Genomic_DNA.
DR   EMBL; BC075898; AAH75898.1; -; mRNA.
DR   RefSeq; NP_001002357.1; NM_001002357.1.
DR   AlphaFoldDB; A2BF66; -.
DR   SMR; A2BF66; -.
DR   STRING; 7955.ENSDARP00000058887; -.
DR   PaxDb; A2BF66; -.
DR   PeptideAtlas; A2BF66; -.
DR   PRIDE; A2BF66; -.
DR   Ensembl; ENSDART00000058888; ENSDARP00000058887; ENSDARG00000040254.
DR   GeneID; 436630; -.
DR   KEGG; dre:436630; -.
DR   CTD; 84072; -.
DR   ZFIN; ZDB-GENE-040718-49; hormad1.
DR   eggNOG; KOG4652; Eukaryota.
DR   GeneTree; ENSGT00390000018130; -.
DR   HOGENOM; CLU_058638_1_0_1; -.
DR   InParanoid; A2BF66; -.
DR   OMA; GNCEGVI; -.
DR   OrthoDB; 1038689at2759; -.
DR   PhylomeDB; A2BF66; -.
DR   TreeFam; TF313989; -.
DR   PRO; PR:A2BF66; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000040254; Expressed in testis and 10 other tissues.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0042138; P:meiotic DNA double-strand break formation; ISS:UniProtKB.
DR   GO; GO:0051598; P:meiotic recombination checkpoint signaling; ISS:UniProtKB.
DR   GO; GO:0051177; P:meiotic sister chromatid cohesion; ISS:UniProtKB.
DR   GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR   GO; GO:0060629; P:regulation of homologous chromosome segregation; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR003511; HORMA_dom.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   Pfam; PF02301; HORMA; 1.
DR   SUPFAM; SSF56019; SSF56019; 1.
DR   PROSITE; PS50815; HORMA; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Differentiation; Meiosis; Nucleus; Oogenesis;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..356
FT                   /note="HORMA domain-containing protein 1"
FT                   /id="PRO_0000284667"
FT   DOMAIN          24..225
FT                   /note="HORMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT   REGION          282..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        9
FT                   /note="P -> H (in Ref. 2; AAH75898)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        312
FT                   /note="A -> V (in Ref. 2; AAH75898)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   356 AA;  40976 MW;  C4FBD24101E649C7 CRC64;
     MTCEQKSRPV QSCQMLPDVV SNEQQSLVLV KKLLAIAISS ITYLRGLFSE KAYGRKYVGE
     LKVYILREDS CPGAQQIVHW LQGCFDALQR RYLRMVLLSI YCDPDNPQKV TECYQFKIKY
     TEKGPQMDFE SKNGQSLTKM ACDNTQKSSM LLVRKLYMLM QNLGPLPDDV CLNMKLLYYD
     EVTPQEYQPP GFKEDDNGTL MFEREPVNLT MGEVVTPFHS IKMNVTTEKK RIEPFEDDVE
     VCVSTKWSLK ISEDGMMSET SVQQECMTKE NVITDAGIEY SETQETQEQP HRHTKEDFST
     NPKMDNLVKK TADLKVDARK TRSGRIFEPQ ISQLEFPLSQ DPQPSVPKRR KVSVPK