HORM1_MACFA
ID HORM1_MACFA Reviewed; 394 AA.
AC Q4R8B9; Q95JJ3; Q95JZ3;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=HORMA domain-containing protein 1;
GN Name=HORMAD1; ORFNames=QtsA-11904, QtsA-12863, QtsA-16861;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 97-394.
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 177-394.
RC TISSUE=Testis;
RA Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K.,
RA Sugano S.;
RT "Isolation of novel full-length cDNA clones from macaque testis cDNA
RT libraries.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION.
RX PubMed=15999985;
RA Chen Y.-T., Venditti C.A., Theiler G., Stevenson B.J., Iseli C., Gure A.O.,
RA Jongeneel C.V., Old L.J., Simpson A.J.G.;
RT "Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen
RT encoding a putative meiosis-related protein.";
RL Cancer Immun. 5:9-9(2005).
CC -!- FUNCTION: Plays a key role in meiotic progression. Regulates 3
CC different functions during meiosis: ensures that sufficient numbers of
CC processed DNA double-strand breaks (DSBs) are available for successful
CC homology search by increasing the steady-state numbers of single-
CC stranded DSB ends. Promotes synaptonemal-complex formation
CC independently of its role in homology search. Plays a key role in the
CC male mid-pachytene checkpoint and the female meiotic prophase
CC checkpoint: required for efficient build-up of ATR activity on
CC unsynapsed chromosome regions, a process believed to form the basis of
CC meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase
CC quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SUBUNIT: Interacts with HORMAD2. Interacts with IHO1.
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}.
CC Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially
CC localizes to unsynapsed or desynapsed chromosomal regions during the
CC prophase I stage of meiosis. TRIP13 is required for depletion from
CC synapsed chromosomes. The expression of the phosphorylated form at Ser-
CC 377 is restricted to unsynapsed chromosomal regions (By similarity).
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- PTM: Phosphorylated at Ser-377 in a SPO11-dependent manner.
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB62979.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB63133.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB168538; BAE00653.1; -; mRNA.
DR EMBL; AB070034; BAB62979.1; ALT_INIT; mRNA.
DR EMBL; AB070188; BAB63133.1; ALT_INIT; mRNA.
DR RefSeq; XP_005542028.1; XM_005541971.2.
DR RefSeq; XP_005542029.1; XM_005541972.2.
DR AlphaFoldDB; Q4R8B9; -.
DR SMR; Q4R8B9; -.
DR STRING; 9541.XP_005542028.1; -.
DR PRIDE; Q4R8B9; -.
DR Ensembl; ENSMFAT00000020530; ENSMFAP00000009464; ENSMFAG00000000795.
DR GeneID; 101867396; -.
DR KEGG; mcf:101867396; -.
DR CTD; 84072; -.
DR VEuPathDB; HostDB:ENSMFAG00000000795; -.
DR eggNOG; KOG4652; Eukaryota.
DR GeneTree; ENSGT00390000018130; -.
DR OMA; GNCEGVI; -.
DR OrthoDB; 1038689at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000000795; Expressed in multicellular organism.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR GO; GO:0001824; P:blastocyst development; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0042138; P:meiotic DNA double-strand break formation; ISS:UniProtKB.
DR GO; GO:0051598; P:meiotic recombination checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0051177; P:meiotic sister chromatid cohesion; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR GO; GO:0060629; P:regulation of homologous chromosome segregation; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; SSF56019; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Differentiation; Meiosis; Nucleus; Oogenesis; Phosphoprotein;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..394
FT /note="HORMA domain-containing protein 1"
FT /id="PRO_0000284665"
FT DOMAIN 24..226
FT /note="HORMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT REGION 252..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 383..386
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000305"
FT COMPBIAS 252..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 376
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D5T7"
FT CONFLICT 283
FT /note="N -> D (in Ref. 3; BAB62979)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 394 AA; 45163 MW; 18B40DB3C68FBA22 CRC64;
MATAQLQRTP MSALVFPNKI STEHQSLVLV KRLLAVSVSC ITYLRGIFPE CAYGTRYLDD
LCVKILREDK NCPGSTQLVK WMLGCYDALQ KKYLRMVVLA VYTNPEDPQT ISECYQFKFK
YTNNGPLMDF ISKNQSNESS MSSTDTKKAS ILLIRKIYIL MQNLGPLPND VCLTMKLFYY
DEVTPPDYQP PGFKDGDCEG VIFEGEPMYL NVGEVSTPFH IFKVKVTTER ERMENIDSTI
LSPKQIKTPF QKILRDKDVE DEQEHYTSDD LDMETKMEEQ EKNPASSELG EPSLVCEEDE
IMRSKESPDL SISHSQVEQL VNKTSELDMS ESKTRSGKVF QNKMANGNQP VKSSKENRKR
SQHESGRRVL HHFDSSSQES VPKRRKFSEP KEHI
