HORM1_RAT
ID HORM1_RAT Reviewed; 392 AA.
AC D3ZWE7; D3ZZR2;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=HORMA domain-containing protein 1;
GN Name=Hormad1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Plays a key role in meiotic progression. Regulates 3
CC different functions during meiosis: ensures that sufficient numbers of
CC processed DNA double-strand breaks (DSBs) are available for successful
CC homology search by increasing the steady-state numbers of single-
CC stranded DSB ends. Promotes synaptonemal-complex formation
CC independently of its role in homology search. Plays a key role in the
CC male mid-pachytene checkpoint and the female meiotic prophase
CC checkpoint: required for efficient build-up of ATR activity on
CC unsynapsed chromosome regions, a process believed to form the basis of
CC meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase
CC quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SUBUNIT: Interacts with HORMAD2. Interacts with IHO1.
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}.
CC Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially
CC localizes to unsynapsed or desynapsed chromosomal regions during the
CC prophase I stage of meiosis. TRIP13 is required for depletion from
CC synapsed chromosomes. The expression of the phosphorylated form at Ser-
CC 375 is restricted to unsynapsed chromosomal regions (By similarity).
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- PTM: Phosphorylated at Ser-375 in a SPO11-dependent manner.
CC {ECO:0000250|UniProtKB:Q9D5T7}.
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DR EMBL; CH474015; EDL85702.1; -; Genomic_DNA.
DR RefSeq; NP_001102419.1; NM_001108949.1.
DR RefSeq; XP_006233013.1; XM_006232951.3.
DR AlphaFoldDB; D3ZWE7; -.
DR SMR; D3ZWE7; -.
DR STRING; 10116.ENSRNOP00000063863; -.
DR CarbonylDB; D3ZWE7; -.
DR iPTMnet; D3ZWE7; -.
DR PhosphoSitePlus; D3ZWE7; -.
DR PaxDb; D3ZWE7; -.
DR PRIDE; D3ZWE7; -.
DR Ensembl; ENSRNOT00000066821; ENSRNOP00000063863; ENSRNOG00000021160.
DR GeneID; 365868; -.
DR KEGG; rno:365868; -.
DR CTD; 84072; -.
DR RGD; 1564960; Hormad1.
DR eggNOG; KOG4652; Eukaryota.
DR GeneTree; ENSGT00390000018130; -.
DR HOGENOM; CLU_058638_1_0_1; -.
DR InParanoid; D3ZWE7; -.
DR OMA; GNCEGVI; -.
DR OrthoDB; 1038689at2759; -.
DR TreeFam; TF313989; -.
DR PRO; PR:D3ZWE7; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Proteomes; UP000234681; Chromosome 2.
DR Bgee; ENSRNOG00000021160; Expressed in testis and 3 other tissues.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0000794; C:condensed nuclear chromosome; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000795; C:synaptonemal complex; ISO:RGD.
DR GO; GO:0001824; P:blastocyst development; ISS:UniProtKB.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; ISO:RGD.
DR GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0042138; P:meiotic DNA double-strand break formation; ISS:UniProtKB.
DR GO; GO:0051598; P:meiotic recombination checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0051177; P:meiotic sister chromatid cohesion; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR GO; GO:0060629; P:regulation of homologous chromosome segregation; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; SSF56019; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 1: Evidence at protein level;
KW Chromosome; Differentiation; Meiosis; Nucleus; Oogenesis; Phosphoprotein;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..392
FT /note="HORMA domain-containing protein 1"
FT /id="PRO_0000410914"
FT DOMAIN 25..227
FT /note="HORMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT REGION 271..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 381..384
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT COMPBIAS 274..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 374
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D5T7"
SQ SEQUENCE 392 AA; 44885 MW; 9988EC445088A9F3 CRC64;
MATMQLRRTA SMSALVFPNK ISTEQQSLMF VKRLLAVSVS CITYLRGIFP ERAYGTRYLD
DLCVKILKED KNCPGSSQLV KWMLGCYDAL QKKYLRMIIL AVYTNPEDPQ TISECYQFKF
KYTKNGPIMD FISKNQNNKS STTSADTKKA SILLIRKIYV LMQNLGPLPN DVCLTMKLFY
YDEVTPPDYQ PPGFKDGDCE GVIFDGDPTY LNVGEVPTPF HTFRLKVTTE KERMENIDSA
ILTPKDSKIP FQKILMDKDD VEDENHNNFD IKTKMNEQNE NSGTSEIKEP NLDCKEEEIM
QFKKNQSSSI SQCQVEQLIS KTSELDVSES KTRSGKIFQC KMVNGNQQGQ ISKENRKRSL
RQSGKTVLHI LESSSQESVL KRRRVSEPNE HT
