HORM1_XENLA
ID HORM1_XENLA Reviewed; 386 AA.
AC Q5M7C8;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=HORMA domain-containing protein 1;
GN Name=hormad1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a key role in meiotic progression by ensuring that
CC sufficient numbers of processed DNA double-strand breaks (DSBs) are
CC available for successful homology search, promoting synaptonemal-
CC complex formation independently and playing key role in the male mid-
CC pachytene checkpoint and the female meiotic prophase checkpoint.
CC {ECO:0000250|UniProtKB:Q9D5T7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}.
CC Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially
CC localizes to unsynapsed or desynapsed chromosomal regions during the
CC prophase I stage of meiosis. {ECO:0000250|UniProtKB:Q9D5T7}.
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DR EMBL; BC088705; AAH88705.1; -; mRNA.
DR RefSeq; NP_001088894.1; NM_001095425.1.
DR AlphaFoldDB; Q5M7C8; -.
DR SMR; Q5M7C8; -.
DR DNASU; 496240; -.
DR GeneID; 496240; -.
DR KEGG; xla:496240; -.
DR CTD; 496240; -.
DR Xenbase; XB-GENE-986781; hormad1.S.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 496240; Expressed in testis and 3 other tissues.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0042138; P:meiotic DNA double-strand break formation; ISS:UniProtKB.
DR GO; GO:0051598; P:meiotic recombination checkpoint signaling; ISS:UniProtKB.
DR GO; GO:0051177; P:meiotic sister chromatid cohesion; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR GO; GO:0060629; P:regulation of homologous chromosome segregation; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR GO; GO:0007130; P:synaptonemal complex assembly; ISS:UniProtKB.
DR Gene3D; 3.30.900.10; -; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; SSF56019; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Differentiation; Meiosis; Nucleus; Oogenesis;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..386
FT /note="HORMA domain-containing protein 1"
FT /id="PRO_0000284668"
FT DOMAIN 24..224
FT /note="HORMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT REGION 237..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 43600 MW; 8800C130F6B7A1FB CRC64;
MATAQMHRNK VNSVALPSRV ATETQSLILV KRLLAVSVSC ITYLRGLFPE YAYGTRYLDD
ICVKILREDK SCPGSTQLVK WMLGCYDALQ KKYLRMVMLA IYTDPEDPQT VTECYQFKFK
YTASGPVMDF VSNNSNSVST CSDAKKTSIL LIRKLYILMQ NLGPLPNDVC LTMKLFYYDE
VTPADYQPPG FKEGTCEGLM FEGEPMYLNV GEVATPFHVL KVKVTTEKER MENIEKSIFK
KQASKQPQTD EEKPDLSIND DLAQDNNGDR KRDDIETLKV EDLNLTCQED GNLQSDDSQN
SALADSQEKT SQAAPPAFGR KTRSGRIFQK PDLELKNQKE SARASKGNQQ ARKPEKRSQS
FEITGSQEDP AVAKRRKFSE PRTPLN