ID   HORM2_BOVIN             Reviewed;         306 AA.
AC   A6QQY4; Q0VBW9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=HORMA domain-containing protein 2;
GN   Name=HORMAD2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for synapsis surveillance during meiotic prophase
CC       via the recruitment of ATR activity. Plays a key role in the male mid-
CC       pachytene checkpoint and the female meiotic prophase checkpoint:
CC       required for efficient build-up of ATR activity on unsynapsed
CC       chromosome regions, a process believed to form the basis of meiotic
CC       silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality
CC       control in both sexes. Required for the DNA double-strand break-
CC       independent, BRCA1-dependent activation of ATR on the sex chromosomes
CC       that is essential for normal sex body formation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with HORMAD1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC       Note=Preferentially localizes to unsynapsed or desynapsed chromosomal
CC       regions during the male and female prophase I stage of meiosis. TRIP13
CC       is required for depletion from synapsed chromosomes (By similarity).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A6QQY4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A6QQY4-2; Sequence=VSP_041564;
CC   -!- PTM: Phosphorylated in a SPO11-dependent manner. {ECO:0000250}.
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DR   EMBL; BC120469; AAI20470.1; -; mRNA.
DR   EMBL; BC150041; AAI50042.1; -; mRNA.
DR   RefSeq; NP_001071611.1; NM_001078143.2. [A6QQY4-2]
DR   AlphaFoldDB; A6QQY4; -.
DR   SMR; A6QQY4; -.
DR   STRING; 9913.ENSBTAP00000029451; -.
DR   PaxDb; A6QQY4; -.
DR   PRIDE; A6QQY4; -.
DR   GeneID; 777596; -.
DR   KEGG; bta:777596; -.
DR   CTD; 150280; -.
DR   eggNOG; KOG4652; Eukaryota.
DR   InParanoid; A6QQY4; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR   GO; GO:0051177; P:meiotic sister chromatid cohesion; ISS:UniProtKB.
DR   Gene3D; 3.30.900.10; -; 1.
DR   InterPro; IPR003511; HORMA_dom.
DR   InterPro; IPR036570; HORMA_dom_sf.
DR   Pfam; PF02301; HORMA; 1.
DR   SUPFAM; SSF56019; SSF56019; 1.
DR   PROSITE; PS50815; HORMA; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chromosome; Meiosis; Nucleus; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..306
FT                   /note="HORMA domain-containing protein 2"
FT                   /id="PRO_0000410915"
FT   DOMAIN          29..232
FT                   /note="HORMA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00109"
FT   VAR_SEQ         1..100
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_041564"
SQ   SEQUENCE   306 AA;  34936 MW;  52DB2376BD921FDE CRC64;
     MATVQLSRSI RIRKTSKKTV FPSQITNEHE SLIMVKKLFA TSISCITYLR GLFPESSYGE
     RHLDDLSLKI LREDKKCPGS LHIIKWIQGC FDALEKRYLR MAVLTLYTNP KEPEKVTEIY
     QFKFKYTKEG ATMDFDSSNT SFKSGTNSED IKKASVLLIR KLYMLMQNLG PLPNDVILTM
     TLHYYNAVTP NDYQPPGFKE GVSSHLLLFE GEPVNLQVGM VSTGFHSMKV KVTTEATRVS
     DLESSLFQES GTTEIAHQGL DCDEEEEECN TEIQKMNFVC SQQSSERSRK KRKVSEPVKV
     FIPDRK