HOS15_ARATH
ID HOS15_ARATH Reviewed; 613 AA.
AC Q9FN19; Q56Y40;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=WD40 repeat-containing protein HOS15 {ECO:0000305};
DE AltName: Full=HIGH OSMOTIC STRESS GENE EXPRESSION 15 {ECO:0000303|PubMed:18356294};
GN Name=HOS15 {ECO:0000303|PubMed:18356294};
GN OrderedLocusNames=At5g67320 {ECO:0000312|Araport:AT5G67320};
GN ORFNames=K8K14.4 {ECO:0000312|EMBL:BAB09017.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-154.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=18356294; DOI=10.1073/pnas.0801029105;
RA Zhu J., Jeong J.C., Zhu Y., Sokolchik I., Miyazaki S., Zhu J.K.,
RA Hasegawa P.M., Bohnert H.J., Shi H., Yun D.J., Bressan R.A.;
RT "Involvement of Arabidopsis HOS15 in histone deacetylation and cold
RT tolerance.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:4945-4950(2008).
CC -!- FUNCTION: Acts as repressor of cold stress-regulated gene expression.
CC Interacts specifically with and promotes deacetylation of histone H4.
CC Plays a role in gene regulation for plant acclimation and tolerance to
CC cold stress. {ECO:0000269|PubMed:18356294}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18356294}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant seedlings are hypersensitive to freezing.
CC {ECO:0000269|PubMed:18356294}.
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DR EMBL; AB007645; BAB09017.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98328.1; -; Genomic_DNA.
DR EMBL; AY057698; AAL15328.1; -; mRNA.
DR EMBL; AY143932; AAN28871.1; -; mRNA.
DR EMBL; AK221483; BAD94649.1; -; mRNA.
DR RefSeq; NP_201533.1; NM_126132.4.
DR AlphaFoldDB; Q9FN19; -.
DR SMR; Q9FN19; -.
DR STRING; 3702.AT5G67320.1; -.
DR PaxDb; Q9FN19; -.
DR PRIDE; Q9FN19; -.
DR ProteomicsDB; 230264; -.
DR EnsemblPlants; AT5G67320.1; AT5G67320.1; AT5G67320.
DR GeneID; 836867; -.
DR Gramene; AT5G67320.1; AT5G67320.1; AT5G67320.
DR KEGG; ath:AT5G67320; -.
DR Araport; AT5G67320; -.
DR TAIR; locus:2158232; AT5G67320.
DR eggNOG; KOG0273; Eukaryota.
DR HOGENOM; CLU_007609_2_0_1; -.
DR InParanoid; Q9FN19; -.
DR OMA; KWNKCGN; -.
DR OrthoDB; 1463197at2759; -.
DR PhylomeDB; Q9FN19; -.
DR PRO; PR:Q9FN19; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FN19; baseline and differential.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:TAIR.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009409; P:response to cold; IMP:TAIR.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045183; Ebi-like.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR22846; PTHR22846; 2.
DR Pfam; PF08513; LisH; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Repeat; Repressor; Stress response;
KW Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..613
FT /note="WD40 repeat-containing protein HOS15"
FT /id="PRO_0000438736"
FT DOMAIN 5..37
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT REPEAT 263..302
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 322..362
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 363..402
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 405..443
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 446..485
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 488..536
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 539..580
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 582..613
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REGION 101..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 69772 MW; 04F40772311C0E76 CRC64;
MSSLTSVELN FLVFRYLQES GFTHAAFTLG YEAGINKSNI DGNMVPPGAL IKFVQKGLQY
MEMEANLSNS EVDIDEDFSF FQPLDLISKD VKELQDMLRE KKRKERDMEK ERDRSKENDK
GVEREHEGDR NRAKEKDRHE KQKERERERE KLEREKERER EKIEREKERE REKMEREIFE
REKDRLKLEK EREIERERER EKIEREKSHE KQLGDADREM VIDQTDKEIA GDGSTGAEPM
DIVMTPTSQT SHIPNSDVRI LEGHTSEVCA CAWSPSASLL ASGSGDATAR IWSIPEGSFK
AVHTGRNINA LILKHAKGKS NEKSKDVTTL DWNGEGTLLA TGSCDGQARI WTLNGELIST
LSKHKGPIFS LKWNKKGDYL LTGSVDRTAV VWDVKAEEWK QQFEFHSGPT LDVDWRNNVS
FATSSTDSMI YLCKIGETRP AKTFTGHQGE VNCVKWDPTG SLLASCSDDS TAKIWNIKQS
TFVHDLREHT KEIYTIRWSP TGPGTNNPNK QLTLASASFD STVKLWDAEL GKMLCSFNGH
REPVYSLAFS PNGEYIASGS LDKSIHIWSI KEGKIVKTYT GNGGIFEVCW NKEGNKIAAC
FADNSVCVLD FRM
