ID   HOSA_ECO11              Reviewed;         135 AA.
AC   Q9F8R8;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Transcriptional regulator HosA;
GN   Name=hosA;
OS   Escherichia coli O111:H-.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=168927;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=O111:H- / DEC 12e / EPEC;
RX   PubMed=10986240; DOI=10.1128/jb.182.19.5381-5390.2000;
RA   Herbelin C.J., Chirillo S.C., Melnick K.A., Whittam T.S.;
RT   "Gene conservation and loss in the mutS-rpoS genomic region of pathogenic
RT   Escherichia coli.";
RL   J. Bacteriol. 182:5381-5390(2000).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=12088660; DOI=10.1016/s0966-842x(02)02374-0;
RA   Heroven A.K., Dersch P.;
RT   "Two different open reading frames named slyA in the E. coli sequence
RT   databases.";
RL   Trends Microbiol. 10:267-268(2002).
CC   -!- FUNCTION: Involved in the temperature-dependent positive control of
CC       flagellum-driven swimming motility and cellular aggregation. Regulates
CC       fliC expression by directly interacting with fliC promoter (By
CC       similarity). {ECO:0000250}.
CC   -!- CAUTION: Originally described as slyA, but then it was found that two
CC       distinct genes had been named slyA. This gene was renamed hosA.
CC       {ECO:0000305}.
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DR   EMBL; AF242208; AAG14974.1; -; Genomic_DNA.
DR   RefSeq; WP_001208070.1; NZ_QMIB01000001.1.
DR   AlphaFoldDB; Q9F8R8; -.
DR   SMR; Q9F8R8; -.
DR   GeneID; 66673386; -.
DR   OMA; WNTMVSE; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..135
FT                   /note="Transcriptional regulator HosA"
FT                   /id="PRO_0000054356"
FT   DOMAIN          4..134
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        48..71
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   135 AA;  15493 MW;  9FA5C9C0F0173714 CRC64;
     MALRNKAFHQ LRQLFQQHTA RWQHELPDLT KPQYAVMRAI ADKPGIEQVA LIEAAVSTKA
     TLAEMLARME NRGLVRREHD PADKRRRFVW LTAEGEKILA AAIPIGDSVD EEFLGRLSGE
     EQELFMQLVR KMMNA