ID   HOSA_ECO27              Reviewed;         135 AA.
AC   P69782; B7UHG0; Q9EUB1;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Transcriptional regulator HosA;
GN   Name=hosA; OrderedLocusNames=E2348C_3010;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10986240; DOI=10.1128/jb.182.19.5381-5390.2000;
RA   Herbelin C.J., Chirillo S.C., Melnick K.A., Whittam T.S.;
RT   "Gene conservation and loss in the mutS-rpoS genomic region of pathogenic
RT   Escherichia coli.";
RL   J. Bacteriol. 182:5381-5390(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/jb.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA   Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA   Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=12088660; DOI=10.1016/s0966-842x(02)02374-0;
RA   Heroven A.K., Dersch P.;
RT   "Two different open reading frames named slyA in the E. coli sequence
RT   databases.";
RL   Trends Microbiol. 10:267-268(2002).
RN   [4]
RP   FUNCTION.
RX   PubMed=15731069; DOI=10.1128/iai.73.3.1684-1694.2005;
RA   Ferrandiz M.-J., Bishop K., Williams P., Withers H.;
RT   "HosA, a member of the SlyA family, regulates motility in enteropathogenic
RT   Escherichia coli.";
RL   Infect. Immun. 73:1684-1694(2005).
CC   -!- FUNCTION: Involved in the temperature-dependent positive control of
CC       flagellum-driven swimming motility and cellular aggregation. Regulates
CC       fliC expression by directly interacting with fliC promoter.
CC       {ECO:0000269|PubMed:15731069}.
CC   -!- INDUCTION: Expression is modulated by temperature, growth phase, salt
CC       and pH.
CC   -!- CAUTION: Originally described as slyA, but then it was found that two
CC       distinct genes had been named slyA. This gene was renamed hosA.
CC       {ECO:0000305}.
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DR   EMBL; AF242211; AAG14991.1; -; Genomic_DNA.
DR   EMBL; FM180568; CAS10558.1; -; Genomic_DNA.
DR   RefSeq; WP_001208066.1; NC_011601.1.
DR   AlphaFoldDB; P69782; -.
DR   SMR; P69782; -.
DR   EnsemblBacteria; CAS10558; CAS10558; E2348C_3010.
DR   KEGG; ecg:E2348C_3010; -.
DR   HOGENOM; CLU_083287_4_0_6; -.
DR   OMA; WNTMVSE; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..135
FT                   /note="Transcriptional regulator HosA"
FT                   /id="PRO_0000054357"
FT   DOMAIN          4..134
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        48..71
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   135 AA;  15497 MW;  141FF8C0F0049284 CRC64;
     MALRNKAFHQ LRQLFQQHTA RWQHELPDLT KPQYAVMRAI ADKPGIEQVA LIEAAVSTKA
     TLAEMLARME NRGLVRREHD AADKRRRFVW LTAEGEKVLA AAIPIGDSVD EEFLGRLSAE
     EQELFMQLVR KMMNT