HOSA_ECO57
ID HOSA_ECO57 Reviewed; 135 AA.
AC Q7ABA6; Q8X7Z5; Q9X729;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transcriptional regulator HosA;
GN Name=hosA; OrderedLocusNames=Z4048, ECs3594;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=O157:H7 / EHEC;
RA Carter P.E., Thomson-Carter F.M.;
RT "Comparison of the mutS-rpoS region from Escherichia coli O157:H7,
RT verocytotoxin-containing and non-verocytotoxin-containing E.coli.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
RN [4]
RP NOMENCLATURE.
RX PubMed=12088660; DOI=10.1016/s0966-842x(02)02374-0;
RA Heroven A.K., Dersch P.;
RT "Two different open reading frames named slyA in the E. coli sequence
RT databases.";
RL Trends Microbiol. 10:267-268(2002).
CC -!- FUNCTION: Involved in the temperature-dependent positive control of
CC flagellum-driven swimming motility and cellular aggregation. Regulates
CC fliC expression by directly interacting with fliC promoter (By
CC similarity). {ECO:0000250}.
CC -!- CAUTION: Originally described as slyA, but then it was found that two
CC distinct genes had been named slyA. This gene was renamed hosA.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG57847.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ006210; CAB43501.1; -; Genomic_DNA.
DR EMBL; AE005174; AAG57847.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000007; BAB37017.1; -; Genomic_DNA.
DR PIR; B91078; B91078.
DR PIR; C85923; C85923.
DR PIR; T44999; T44999.
DR RefSeq; NP_311621.1; NC_002695.1.
DR RefSeq; WP_000175365.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q7ABA6; -.
DR SMR; Q7ABA6; -.
DR STRING; 155864.EDL933_3909; -.
DR EnsemblBacteria; AAG57847; AAG57847; Z4048.
DR EnsemblBacteria; BAB37017; BAB37017; ECs_3594.
DR GeneID; 914684; -.
DR KEGG; ece:Z4048; -.
DR KEGG; ecs:ECs_3594; -.
DR PATRIC; fig|386585.9.peg.3757; -.
DR eggNOG; COG1846; Bacteria.
DR HOGENOM; CLU_083287_4_0_6; -.
DR OMA; WNTMVSE; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR PRINTS; PR00598; HTHMARR.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Transcription; Transcription regulation;
KW Virulence.
FT CHAIN 1..135
FT /note="Transcriptional regulator HosA"
FT /id="PRO_0000054358"
FT DOMAIN 4..134
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT DNA_BIND 48..71
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ SEQUENCE 135 AA; 15509 MW; 96024FD0F11B5BA3 CRC64;
MTLRNKAFHQ LRQLFQQHTA RWQHELPDLT KPQYAVMRAI ADKPGIEQVA LIEAAVSTKA
TLAEMLARME NRGLVRREHD AADKRRRFVW LTAEGEKILA AAIPIGDSVD EEFLGRLSAE
EQELFVQLVR KMMNT