ID   HOSA_ECOLX              Reviewed;         135 AA.
AC   Q93CC3; Q9EUB1; Q9F8R2;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Transcriptional regulator HosA;
GN   Name=hosA;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=O26:NM / DEC 9f / EHEC, and O55:H6 / DEC 1a / EPEC;
RX   PubMed=10986240; DOI=10.1128/jb.182.19.5381-5390.2000;
RA   Herbelin C.J., Chirillo S.C., Melnick K.A., Whittam T.S.;
RT   "Gene conservation and loss in the mutS-rpoS genomic region of pathogenic
RT   Escherichia coli.";
RL   J. Bacteriol. 182:5381-5390(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 36-135.
RC   STRAIN=BJ4;
RX   PubMed=11810263; DOI=10.1007/s00438-001-0610-0;
RA   Atlung T., Nielsen H.V., Hansen F.G.;
RT   "Characterisation of the allelic variation in the rpoS gene in thirteen K12
RT   and six other non-pathogenic Escherichia coli strains.";
RL   Mol. Genet. Genomics 266:873-881(2002).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=12088660; DOI=10.1016/s0966-842x(02)02374-0;
RA   Heroven A.K., Dersch P.;
RT   "Two different open reading frames named slyA in the E. coli sequence
RT   databases.";
RL   Trends Microbiol. 10:267-268(2002).
CC   -!- FUNCTION: Involved in the temperature-dependent positive control of
CC       flagellum-driven swimming motility and cellular aggregation. Regulates
CC       fliC expression by directly interacting with fliC promoter (By
CC       similarity). {ECO:0000250}.
CC   -!- CAUTION: Originally described as slyA, but then it was found that two
CC       distinct genes had been named slyA. This gene was renamed hosA. It is
CC       not present in strain K12. {ECO:0000305}.
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DR   EMBL; AF242209; AAG14980.1; -; Genomic_DNA.
DR   EMBL; AF242210; AAG14987.1; -; Genomic_DNA.
DR   EMBL; AF410776; AAL01413.1; -; Genomic_DNA.
DR   RefSeq; WP_001208066.1; NZ_WTRA01000012.1.
DR   AlphaFoldDB; Q93CC3; -.
DR   SMR; Q93CC3; -.
DR   STRING; 585034.ECIAI1_2839; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation; Virulence.
FT   CHAIN           1..135
FT                   /note="Transcriptional regulator HosA"
FT                   /id="PRO_0000054355"
FT   DOMAIN          4..134
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        48..71
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   VARIANT         81
FT                   /note="A -> P (in strain: DEC 9f)"
FT   VARIANT         81
FT                   /note="A -> S (in strain: BJ4)"
FT   VARIANT         98
FT                   /note="V -> I (in strain: DEC 9f)"
FT   VARIANT         119
FT                   /note="A -> G (in strain: DEC 9f and BJ4)"
FT   VARIANT         121
FT                   /note="E -> K (in strain: DEC 9f)"
FT   VARIANT         135
FT                   /note="T -> A (in strain: DEC 9f and BJ4)"
SQ   SEQUENCE   135 AA;  15497 MW;  141FF8C0F0049284 CRC64;
     MALRNKAFHQ LRQLFQQHTA RWQHELPDLT KPQYAVMRAI ADKPGIEQVA LIEAAVSTKA
     TLAEMLARME NRGLVRREHD AADKRRRFVW LTAEGEKVLA AAIPIGDSVD EEFLGRLSAE
     EQELFMQLVR KMMNT