ID   HOT1_ASHGO              Reviewed;         629 AA.
AC   Q755E7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=High-osmolarity-induced transcription protein 1;
GN   Name=HOT1; OrderedLocusNames=AFL124C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Required for a complete transcriptional response to osmotic
CC       stress. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HOT1 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53250.1; -; Genomic_DNA.
DR   RefSeq; NP_985426.1; NM_210780.1.
DR   AlphaFoldDB; Q755E7; -.
DR   SMR; Q755E7; -.
DR   STRING; 33169.AAS53250; -.
DR   EnsemblFungi; AAS53250; AAS53250; AGOS_AFL124C.
DR   GeneID; 4621653; -.
DR   KEGG; ago:AGOS_AFL124C; -.
DR   eggNOG; ENOG502QQ7G; Eukaryota.
DR   HOGENOM; CLU_023418_0_0_1; -.
DR   InParanoid; Q755E7; -.
DR   OMA; IWDEYTI; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0060963; P:positive regulation of ribosomal protein gene transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR022210; TF_GCR1-like.
DR   Pfam; PF12550; GCR1_C; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..629
FT                   /note="High-osmolarity-induced transcription protein 1"
FT                   /id="PRO_0000289668"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..423
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..490
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   629 AA;  69019 MW;  48E50724F704267F CRC64;
     MIDPVTHIVT PSNDEQRQGR SDGGMQLGLE DLHGGGGGLG QQKVSGMAEG TDSIVDVLTN
     PSSSVNLHSN ILSVSTNVEE GQGMQPAAIQ GGGTAAGRRF SSVPISDSPV GCGQHGMGTA
     STQVPSHGST ANLLSMGNPV ATNVQVCQRM DEVSARLIVM EETVNKLLGN IDAQQQQIAS
     MRSESMEMLG SLMKEVRELK QQVPVLDDPD NNEKDKFVTD LLNSITNVSS NYLKKVSSRN
     LQRFKRQRDI MSTSDLPSLG NTQSSSHFMQ DLVNPYASTQ DFQSFTVLKD KAKEFTLNPT
     AINKRRRLSA QPLNTLQMSQ DQLQQQRGSV QSLISIPTSG QKNANFGPQL QNYLIGLQNI
     PMSEAEKVSS PTVLKQFQNS TTDPDLKTGR RNPGLDFQIG SGDDENDEND GASGEDEDGY
     LEDDEGYRSQ SQRTMSSEDD EQFTGGNQGE DEAGPRAAGR NPKSLPSSIV RRFANSGSQV
     SVSGTPETER LVLKNNDKYD KNTMPAPNTK PRAVLASNPE DTLTDVQYTM VKAPDSVRAI
     WDEYTIGVGG KPSIRQLEQT YGNKWRTKRN KKTFARRKRI YKFILNGVRN GKSESEMIDI
     LESRRVYRTE DNELKKRTIG WLQQSLSGI