ID   HOT1_CANGA              Reviewed;         658 AA.
AC   Q6FRG0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=High-osmolarity-induced transcription protein 1;
GN   Name=HOT1; OrderedLocusNames=CAGL0H08866g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for a complete transcriptional response to osmotic
CC       stress. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HOT1 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG60117.1; -; Genomic_DNA.
DR   RefSeq; XP_447184.1; XM_447184.1.
DR   AlphaFoldDB; Q6FRG0; -.
DR   SMR; Q6FRG0; -.
DR   STRING; 5478.XP_447184.1; -.
DR   EnsemblFungi; CAG60117; CAG60117; CAGL0H08866g.
DR   GeneID; 2888634; -.
DR   KEGG; cgr:CAGL0H08866g; -.
DR   CGD; CAL0131714; CAGL0H08866g.
DR   VEuPathDB; FungiDB:CAGL0H08866g; -.
DR   eggNOG; ENOG502QQ7G; Eukaryota.
DR   HOGENOM; CLU_023418_0_0_1; -.
DR   InParanoid; Q6FRG0; -.
DR   OMA; KTIWEEY; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022210; TF_GCR1-like.
DR   Pfam; PF12550; GCR1_C; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..658
FT                   /note="High-osmolarity-induced transcription protein 1"
FT                   /id="PRO_0000289669"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        392..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        449..466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..505
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..550
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  73097 MW;  9D4A64481B044DBA CRC64;
     MSDAGDSKLA KEQSDASTGT CNGNGTGNGT GSGTATANAT TTPTPTPTSI PTAAGSVTDV
     TATSSMVLAK LDDISSRLTM LESNFNNVFS KINDQNSMIL DLKQNNSHAF LRLSSKVNKL
     ETHVAALASN NPQSAFVTDL LNSITNVSSS YLRKMKHNGA ENLNVQLSTH ENGFVHPTPN
     DSPNMMGPIY YNQIETSKAR GQLKSLNRKK TFTLNPNGIK KRRLGHHHGN SGSRSNNLNV
     TFDITGQVGQ PGYDTSLNSA TPNNHAMTPS NVISSSNSYS ELQSLNGLQS NTTASDGRTL
     SPVNTVQALK TPYLTATNQH SLNHGSLNNY NLNFPQFLDN TNSVTLSRLG SSSPVEKRDG
     IVMSHSAPQL DNGSITYPDN RLHIRNQASQ DILGGASQGQ PQKINNIDED GYQEDDEEEE
     SELNKHKNKV GNLKYNTTLT DSHSINDDRK PTVNVYASTG HPVNNTKSEY LEDDESNDSD
     NSHETDEESE DEVEEYDEED DMVNEEDRQP YSRKPKEPAS ERKRKKLRKI NKYRNNVIEP
     RKKDDKEKDA QNSDLNYMLL KAPSSVKTIW EEYVNGIDGN PSIRGLEEKY GNKWRIKRNK
     KTFSRRKRLY KFILNGIDKG KTADEMIDML EKQRLYRDEN GEIKRRTIGW LQQSLIGI