ID   HOT1_KLULA              Reviewed;         679 AA.
AC   Q6CR76;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=High-osmolarity-induced transcription protein 1;
GN   Name=HOT1; OrderedLocusNames=KLLA0D11264g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for a complete transcriptional response to osmotic
CC       stress. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HOT1 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00659.1; -; Genomic_DNA.
DR   RefSeq; XP_453563.1; XM_453563.1.
DR   AlphaFoldDB; Q6CR76; -.
DR   STRING; 28985.XP_453563.1; -.
DR   EnsemblFungi; CAH00659; CAH00659; KLLA0_D11264g.
DR   GeneID; 2893219; -.
DR   KEGG; kla:KLLA0_D11264g; -.
DR   eggNOG; ENOG502QQ7G; Eukaryota.
DR   HOGENOM; CLU_404926_0_0_1; -.
DR   InParanoid; Q6CR76; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022210; TF_GCR1-like.
DR   Pfam; PF12550; GCR1_C; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..679
FT                   /note="High-osmolarity-induced transcription protein 1"
FT                   /id="PRO_0000289670"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..546
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..379
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..459
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..475
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  73929 MW;  C66CD4E8D8CFF45D CRC64;
     MSAMENRKNS LHGSPNGLSG LNMVLPREGD SNNGIMTTED ARNGKLKGDK DLNMKMHVGM
     GTTPINTRLG NTMNSDVANS MSYLLEQPQS GTLIGDRLIL ETSEEPVGVN LVDGQNARNN
     QQMLNNASHM DPAFTLPADD TMNNSAAAAA AAAAAAAAST GPSQPTMQST PSISTGGSTN
     FQVQIAQRLA DIDQRILRME MLMDNVCNKI DSHSQQQSLW KNDMHQMENK VIDVLDEIKS
     NIFSLKRQVS NQGDGAFAAE LINAISNVSN KHIRKNTYGF PAGNPQGNDM GQTMNGYNNA
     MQLSSMAAPM SYVPGEQVNL NQLGNSKDQI DRFLTKSANE FMLDPSGLKK RRKNPSSSNE
     SPITLSHTKT HSTSQPINYS ASLPNLNLDA LSKVMLPQHQ QLTHNGGSQH PLSDKSIKFG
     ISSTSHSSSN SSDSDDEEDD IDDEEDEAED EEDENDDSRD VNDHDNVEGR ETLTKKSMKP
     GNSIEGRDPS GTNGTVNSTT NNHMNTIDTA TNTSSQLQGT VIRSTADTEN PKQESNASAA
     ATSGAATGVA TGTTTANIAT SASDKLKLHG DSKKEPKFTM IKAPSSVKEI WREYTQGIDG
     RPSIKSLDQK FGNKWRANKN KKTYSRRKRM YKFILNGIKK GKSEEEMVQM LENKRIYKDS
     DGNQKKRTIG WLQQSLSGI