ID   HOX12_ORYSI             Reviewed;         239 AA.
AC   A2XDK5; A5JPU8; Q6Q7D8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Homeobox-leucine zipper protein HOX12;
DE   AltName: Full=HD-ZIP protein HOX12;
DE   AltName: Full=Homeodomain transcription factor HOX12;
DE   AltName: Full=OsHox12;
GN   Name=HOX12; ORFNames=OsI_010148;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 28-239 AND 67-203, TISSUE SPECIFICITY, GENE
RP   FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Minghui 86, and cv. Pokkali;
RX   PubMed=17999151; DOI=10.1007/s11103-007-9255-7;
RA   Agalou A., Purwantomo S., Oevernaes E., Johannesson H., Zhu X., Estiati A.,
RA   de Kam R.J., Engstroem P., Slamet-Loedin I.H., Zhu Z., Wang M., Xiong L.,
RA   Meijer A.H., Ouwerkerk P.B.F.;
RT   "A genome-wide survey of HD-Zip genes in rice and analysis of drought-
RT   responsive family members.";
RL   Plant Mol. Biol. 66:87-103(2008).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, stems, leaf sheaths
CC       and panicles. {ECO:0000269|PubMed:17999151}.
CC   -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS83422.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR   EMBL; CM000128; EAY88915.1; -; Genomic_DNA.
DR   EMBL; AY554034; AAS83422.1; ALT_SEQ; mRNA.
DR   EMBL; EF555533; ABQ57274.1; -; mRNA.
DR   AlphaFoldDB; A2XDK5; -.
DR   SMR; A2XDK5; -.
DR   STRING; 39946.A2XDK5; -.
DR   EnsemblPlants; BGIOSGA011276-TA; BGIOSGA011276-PA; BGIOSGA011276.
DR   Gramene; BGIOSGA011276-TA; BGIOSGA011276-PA; BGIOSGA011276.
DR   HOGENOM; CLU_100008_0_0_1; -.
DR   OMA; YAYNNYM; -.
DR   Proteomes; UP000007015; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR045224; HDZip_class_I_plant.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   PANTHER; PTHR24326; PTHR24326; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..239
FT                   /note="Homeobox-leucine zipper protein HOX12"
FT                   /id="PRO_0000331696"
FT   DNA_BIND        58..117
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          22..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          107..168
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   239 AA;  26123 MW;  F39FCCE6EEDF6F18 CRC64;
     MSREEEEKLL FPSFAFPAEC FPEAATSGGE QKKARQRRRR KVKPEAAAAL AGESGGDEQA
     KKRRLSDEQA RFLEMSFKKE RKLETPRKVQ LAAELGLDAK QVAVWFQNRR ARHKSKLMEE
     EFAKLRSAHD AVVLQNCHLE TELLKLKERL ADVEEEKAKL AAVAAATTGG GGGGGGGSSS
     PTSSSFSTVT YHPVLAGQFG VEAAAEEADL TYMSEYAYNS YMLELAAAGY CGGVYDQFS