ID   HOX16_ORYSI             Reviewed;         345 AA.
AC   A2X980; A5JPV2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Homeobox-leucine zipper protein HOX16;
DE   AltName: Full=HD-ZIP protein HOX16;
DE   AltName: Full=Homeodomain transcription factor HOX16;
DE   AltName: Full=OsHox16;
GN   Name=HOX16; ORFNames=OsI_008623;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 104-278, TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RC   STRAIN=cv. Minghui 86;
RX   PubMed=17999151; DOI=10.1007/s11103-007-9255-7;
RA   Agalou A., Purwantomo S., Oevernaes E., Johannesson H., Zhu X., Estiati A.,
RA   de Kam R.J., Engstroem P., Slamet-Loedin I.H., Zhu Z., Wang M., Xiong L.,
RA   Meijer A.H., Ouwerkerk P.B.F.;
RT   "A genome-wide survey of HD-Zip genes in rice and analysis of drought-
RT   responsive family members.";
RL   Plant Mol. Biol. 66:87-103(2008).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in seedlings, stems, leaf sheaths and
CC       blades and panicles. {ECO:0000269|PubMed:17999151}.
CC   -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM000127; EAY87390.1; -; Genomic_DNA.
DR   EMBL; EF555537; ABQ57278.1; -; mRNA.
DR   AlphaFoldDB; A2X980; -.
DR   SMR; A2X980; -.
DR   STRING; 39946.A2X980; -.
DR   EnsemblPlants; BGIOSGA008976-TA; BGIOSGA008976-PA; BGIOSGA008976.
DR   Gramene; BGIOSGA008976-TA; BGIOSGA008976-PA; BGIOSGA008976.
DR   HOGENOM; CLU_060842_2_0_1; -.
DR   OMA; HMLEKSF; -.
DR   Proteomes; UP000007015; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR045224; HDZip_class_I_plant.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR003106; Leu_zip_homeo.
DR   PANTHER; PTHR24326; PTHR24326; 1.
DR   Pfam; PF02183; HALZ; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..345
FT                   /note="Homeobox-leucine zipper protein HOX16"
FT                   /id="PRO_0000331704"
FT   DNA_BIND        76..135
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          134..178
FT                   /note="Leucine-zipper"
FT   REGION          220..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  37728 MW;  1DDC5687BD118E6F CRC64;
     MESGRLIFST AGSGAGQMLF LDCGAGGGGG GVGGGAMFHR GARPVLGMEE GGRGVKRPFF
     TTPDELLEEE YYDEQLPEKK RRLTPEQVHL LERSFEEENK LEPERKTELA RKLGLQPRQV
     AVWFQNRRAR WKTKQLERDF DRLKASFDAL RADHDALLQD NHRLHSQVMS LTEKLQEKET
     TTEGSAGAAV DVPGLPAAAD VKVAVPDAEE PALEEAAAAF EEQQEQQVKA EDRLSTGSGG
     SAVVDTDAQL VVGCGRQHLA AVDSSVESYF PGGDEYHDCV MGPMDHAAGG IQSEEDDGAG
     SDEGCSYYAD DAGVLFADHG HHHHHQHADD DEEDGQQISC WWMWN