ID   HOX18_ORYSI             Reviewed;         256 AA.
AC   A2YGL9; A5JPV4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Homeobox-leucine zipper protein HOX18;
DE   AltName: Full=HD-ZIP protein HOX18;
DE   AltName: Full=Homeodomain transcription factor HOX18;
DE   AltName: Full=OsHox18;
GN   Name=HOX18; ORFNames=OsI_023462;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 17-160, TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RC   STRAIN=cv. Minghui 86;
RX   PubMed=17999151; DOI=10.1007/s11103-007-9255-7;
RA   Agalou A., Purwantomo S., Oevernaes E., Johannesson H., Zhu X., Estiati A.,
RA   de Kam R.J., Engstroem P., Slamet-Loedin I.H., Zhu Z., Wang M., Xiong L.,
RA   Meijer A.H., Ouwerkerk P.B.F.;
RT   "A genome-wide survey of HD-Zip genes in rice and analysis of drought-
RT   responsive family members.";
RL   Plant Mol. Biol. 66:87-103(2008).
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaf sheaths and blades and
CC       panicles. {ECO:0000269|PubMed:17999151}.
CC   -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CM000131; EAZ02230.1; -; Genomic_DNA.
DR   EMBL; EF555539; ABQ57280.1; -; mRNA.
DR   AlphaFoldDB; A2YGL9; -.
DR   SMR; A2YGL9; -.
DR   STRING; 39946.A2YGL9; -.
DR   EnsemblPlants; BGIOSGA020603-TA; BGIOSGA020603-PA; BGIOSGA020603.
DR   Gramene; BGIOSGA020603-TA; BGIOSGA020603-PA; BGIOSGA020603.
DR   HOGENOM; CLU_049516_3_0_1; -.
DR   OMA; EDSFRVH; -.
DR   Proteomes; UP000007015; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR003106; Leu_zip_homeo.
DR   Pfam; PF02183; HALZ; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00340; HALZ; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..256
FT                   /note="Homeobox-leucine zipper protein HOX18"
FT                   /id="PRO_0000331708"
FT   DNA_BIND        112..171
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          52..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..214
FT                   /note="Leucine-zipper"
FT   COMPBIAS        52..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        78
FT                   /note="M -> L (in Ref. 2; ABQ57280)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        92
FT                   /note="R -> P (in Ref. 2; ABQ57280)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="S -> G (in Ref. 2; ABQ57280)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   256 AA;  27595 MW;  934CBEF533B0F38D CRC64;
     MEGEDLGSWL GLGIGGGGYA YGGDDCRRSP SSPSPVQMLF SQHVKEEITR GYDHGRDEEQ
     ASGSKIMKGE RGARLRVMRS IRNSGGDGSR SRVLSLGDDG GDGGSGSGGG GGTRKKLQLT
     KEQSTLLEDS FRVHNILSHA QKHELARQLK LKPRQVEVWF QNRRARTKLK QTEVDCEFLK
     RCCESLTEEN KQLKHELMEL RRLASAAAAA AGSQLYVQFP RAAAAAMVNV CPSCEKVTVM
     GGGGGETGKS SSSYSS