ID   HOX1_HALRO              Reviewed;         741 AA.
AC   P28468;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Homeobox protein AHox1;
GN   Name=AHOX1;
OS   Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=7729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1679006; DOI=10.1242/dev.111.3.821;
RA   Saiga H., Mizokami A., Makabe K.W., Satoh N., Mita T.;
RT   "Molecular cloning and expression of a novel homeobox gene AHox1 of the
RT   ascidian, Halocynthia roretzi.";
RL   Development 111:821-828(1991).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the tissues of endodermal origin.
CC   -!- DEVELOPMENTAL STAGE: Associated with differentiation of the endodermal
CC       tissues.
CC   -!- SIMILARITY: Belongs to the H2.0 homeobox family. {ECO:0000305}.
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DR   EMBL; X58996; CAA41742.1; -; Genomic_DNA.
DR   PIR; JS0606; JS0606.
DR   AlphaFoldDB; P28468; -.
DR   SMR; P28468; -.
DR   PRIDE; P28468; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..741
FT                   /note="Homeobox protein AHox1"
FT                   /id="PRO_0000049138"
FT   DNA_BIND        645..704
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          357..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          476..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          722..741
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..78
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..383
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        478..501
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   741 AA;  84777 MW;  3503CEEE2E9FCB8F CRC64;
     MEKMHSKSVS PVPFNNSNNT SLGGLRKSSS IPTLAVPECE SMGNKHIEEE RTNNITTMAM
     KRRLLDPQNK KKQNRFERYS SSNHAQEQSS EENFCRSKKD STVLKFGIDS ILKNKNAEKV
     PKGISNAGRI QDERFTEACT NTSSNVNPLS KYFKPSSNDQ LGARRTATSF SSSSEASDSK
     SCCTNNNEEA RYKYRVIDKR KSADSDWSED ATGNEADDPD DHINQDNCDL ASTLEQSRIV
     ALEILKNKRL RLDSSEALND LTPYDQLSRT EDQQISRRVE MMNHQAFARE NNEWPRSFSS
     GLQDPFAKNL PNAFLPFYMQ PYLRAYYNIQ KYIYHKKLLN RNDRFYREAN VENDNYKTEE
     SLRSPSETKQ YSPDASTFYP IRTEDSNGSR NLKVDVEEGD KEANKLFKDL CVSVGDRLSN
     ALSYGRKDYN GLSTSQTSGN RFLNFSDKGI QAGSYYQTGE RNDSLAGPLK NSGMSFDFPP
     KFGSNNSSTD KPEQEDNNPQ TIGSEYQINT QRSMKDNLLT AKLLENEAKL RYGNIVTQYP
     RPFSWPFAAS VRKSYDPALR SYFSRFNNSD APHYGAAQVN PTAGNNFKSM LPGNFENPYF
     FNELNTLDTT GFLSRQYGHM SSSQNPHSET QNRSEEVRGT VKKRRKWNRA VFSLMQRRGL
     EKSFQSQKYV AKPERRKLAD ALSLTDAQVK IWFQNRRMKW RQEIKMKNRG LVPVHILGQD
     HEIEKEKTQT PSDEGEVINV D