HOX2_ORYSI
ID HOX2_ORYSI Reviewed; 308 AA.
AC Q84U86; A2Y933; A5JPT9; Q9XH39;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Homeobox-leucine zipper protein HOX2;
DE AltName: Full=HD-ZIP protein HOX2;
DE AltName: Full=Homeodomain transcription factor HOX2;
DE AltName: Full=OsHox2;
GN Name=HOX2; ORFNames=OsI_020826;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Shanyou 63; TISSUE=Seed embryo;
RA Shen W.-B., Ye M.-B., Huang L.-Q.;
RT "Characterization of the new HD-Zip gene of Oryza sativa.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 22-308, FUNCTION, SUBUNIT, AND TISSUE
RP SPECIFICITY.
RC STRAIN=cv. IR58; TISSUE=Seed embryo;
RX PubMed=10732669; DOI=10.1007/pl00008671;
RA Meijer A.H., de Kam R.J., d'Erfurth I., Shen W.-B., Hoge J.H.C.;
RT "HD-Zip proteins of families I and II from rice: interactions and
RT functional properties.";
RL Mol. Gen. Genet. 263:12-21(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 94-220, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Minghui 86;
RX PubMed=17999151; DOI=10.1007/s11103-007-9255-7;
RA Agalou A., Purwantomo S., Oevernaes E., Johannesson H., Zhu X., Estiati A.,
RA de Kam R.J., Engstroem P., Slamet-Loedin I.H., Zhu Z., Wang M., Xiong L.,
RA Meijer A.H., Ouwerkerk P.B.F.;
RT "A genome-wide survey of HD-Zip genes in rice and analysis of drought-
RT responsive family members.";
RL Plant Mol. Biol. 66:87-103(2008).
CC -!- FUNCTION: Probable transcription factor that binds to the DNA sequence
CC 5'-CAAT[GC]ATTG-3'. {ECO:0000269|PubMed:10732669}.
CC -!- SUBUNIT: Homodimer (Probable). May form a heterodimer with HOX1, HOX3
CC or HOX7. {ECO:0000269|PubMed:10732669, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, leaves, nodes,
CC internodes, flowers and embryo. {ECO:0000269|PubMed:10732669,
CC ECO:0000269|PubMed:17999151}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class II subfamily.
CC {ECO:0000305}.
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DR EMBL; AY206864; AAO47728.1; -; mRNA.
DR EMBL; CM000131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF145726; AAD37695.1; -; mRNA.
DR EMBL; EF555522; ABQ57265.1; -; mRNA.
DR AlphaFoldDB; Q84U86; -.
DR SMR; Q84U86; -.
DR STRING; 39946.Q84U86; -.
DR EnsemblPlants; BGIOSGA022272-TA; BGIOSGA022272-PA; BGIOSGA022272.
DR Gramene; BGIOSGA022272-TA; BGIOSGA022272-PA; BGIOSGA022272.
DR HOGENOM; CLU_049516_4_0_1; -.
DR OMA; QQQCHPK; -.
DR Proteomes; UP000007015; Chromosome 6.
DR ExpressionAtlas; Q84U86; differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003106; Leu_zip_homeo.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00340; HALZ; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..308
FT /note="Homeobox-leucine zipper protein HOX2"
FT /id="PRO_0000331676"
FT DNA_BIND 112..171
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 15..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..214
FT /note="Leucine-zipper"
FT COMPBIAS 89..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 254
FT /note="T -> I (in Ref. 3; AAD37695)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 32085 MW; BB48CD9EFE5EFFC8 CRC64;
MMDLGLSLGL GLASQGSLTS STTTTSSPGA GSSSPWAAAL NSIVGDVRRD QAAAHAAAAV
GVGVGGEEMY QGRASTSPDS AAALSSASGK RERELERSGS GVDDDDGADG AGGRKKLRLS
KDQAAVLEEC FKTHSTLNPK QKVALANRLG LRPRQVEVWF QNRRARTKLK QTEVDCEYLK
RWCERLADEN KRLEKELADL RALKAAPSPA SASAMQPSSS AAATLTMCPS CRRVATAGAP
HQPNHQQCHP KSNTTISSSS TAAAAVAVAG GNVLPSHCQF FPAAAAAADR TSQSTWNAAA
PLVTRELF
