HOX3_BRAFL
ID HOX3_BRAFL Reviewed; 411 AA.
AC P50901;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Homeobox protein HOX3;
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1363226; DOI=10.1242/dev.116.3.653;
RA Holland P.W., Holland L.Z., Williams N.A., Holland N.D.;
RT "An amphioxus homeobox gene: sequence conservation, spatial expression
RT during development and insights into vertebrate evolution.";
RL Development 116:653-661(1992).
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DEVELOPMENTAL STAGE: Localized expression of in the posterior mesoderm
CC (but not in the somites), and region-specific expression in the dorsal
CC nerve cord, of amphioxus neurulae, later embryos and larvae. The
CC anterior limit to expression in the nerve cord is at the level of the
CC four/five somite boundary at the neurula stage, and stabilizes to just
CC anterior to the first nerve cord pigment spot to form.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; X68045; CAA48180.1; -; Genomic_DNA.
DR PIR; A49127; A49127.
DR AlphaFoldDB; P50901; -.
DR SMR; P50901; -.
DR STRING; 7739.XP_002612717.1; -.
DR eggNOG; KOG0489; Eukaryota.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..411
FT /note="Homeobox protein HOX3"
FT /id="PRO_0000200274"
FT DNA_BIND 135..194
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 51..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 192..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 98..103
FT /note="Antp-type hexapeptide"
FT COMPBIAS 52..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..231
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..317
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 411 AA; 44005 MW; 84740EDF2FB574A1 CRC64;
MQKSPYYETT SQQLYNGYSY SNGERFGYEG SGGGGGGGSY GAEVTQDFGP SCSVRKPGST
TGGGTGNVSP TCMKTNPADN NHGSAPQSNA SILANTKIYP WMKESRQNSK QRQQPNLSVG
TTEPGESPGL GGAAGKRART AYTSAQLVEL EKEFHFNRYL CRPRRVEMAA MLNLTERQIK
IWFQNRRMKY KKEQKVKGGG SGGGSGGMNS PSPPATTTPP GINPGPLPHP TTQPSLSQSN
NMSNHMSMMG SLQQTQPAYS QYPPPHLNHS LPHQAPPHSV GLTMSGPVSP QCYQSNHSPC
PPSSAPHPVP MGNHVPHPRQ GPPHMTNGLP ASPLEVVSQR QYTPPAPGPS PTGPGPGHHG
LTNSYPECPP HHTELPHHQY STPMSVVNMN YCVNVQTQGN RLNSAPKLTH L
