ID   HOX3_XENLA              Reviewed;         388 AA.
AC   P50476; A5PKP7;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Homeobox protein XHOX-3;
GN   Name=xhox3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Ruiz i Altaba A., Choi T., Melton D.A.;
RT   "Expression of the Xhox3 homeobox protein in Xenopus embryos: blocking its
RT   early function suggests the requirement of Xhox3 for normal posterior
RT   development.";
RL   Dev. Growth Differ. 33:651-669(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 168-227.
RX   PubMed=2576399; DOI=10.1242/dev.106.1.173;
RA   Ruiz i Altaba A., Melton D.A.;
RT   "Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during
RT   embryonic development.";
RL   Development 106:173-183(1989).
CC   -!- FUNCTION: May be required for posterior development and development of
CC       normal embryonic axial pattern.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: It is first expressed at the midblastula
CC       transition and is maximally expressed at the late gastrula-early
CC       neurula stage. It is expressed in two distinct periods, the early
CC       period is characterized by an anteroposterior graded expression in the
CC       mesoderm with the highest concentration at the posterior end. The late
CC       period begins at the tailbud stage and is characterized by new
CC       expression in the CNS, predominantly in the brain, and in addition it
CC       is also expressed in the tail bud at this stage.
CC   -!- SIMILARITY: Belongs to the even-skipped homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D10455; BAA01250.1; -; mRNA.
DR   EMBL; BC142567; AAI42568.1; -; mRNA.
DR   PIR; A60092; A60092.
DR   RefSeq; NP_001084320.1; NM_001090851.1.
DR   AlphaFoldDB; P50476; -.
DR   SMR; P50476; -.
DR   GeneID; 399437; -.
DR   KEGG; xla:399437; -.
DR   CTD; 399437; -.
DR   Xenbase; XB-GENE-865004; evx1.L.
DR   OrthoDB; 836887at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 399437; Expressed in neurula embryo and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..388
FT                   /note="Homeobox protein XHOX-3"
FT                   /id="PRO_0000049144"
FT   DNA_BIND        168..227
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          30..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   388 AA;  42023 MW;  0255FA59B7D16586 CRC64;
     MEGRKEMLMY LEGGQLGTLV GKRMAHLSDA VGSPMAESQD KLVPKSPRAG PIAPTDRAEE
     SEVEVGQATG QQRSRSPQLR ISSPHPPAHS DSLSTKGQHS SSDTESDFYE EIEVSCTPDC
     NSAASDYQQH SAGQCSEPMG GSPVNGSDSS KGGGGSHGSF SACAGDQMRR YRTAFTREQI
     ARLEKEFYRE NYVSRPRRCE LAAALNLPET TIKVWFQNRR MKDKRQRLAM TWPHPADPAF
     YTYMMSHAAA TGNLPYPFPS HLPLPYYSHM GISAGSTAAA TPFSAPLRPL DTFRVLSHPY
     PRPDLLCAFR HPSIYASPAH GLGSGGSPCS CLACLSTSTN GLGQRAAASD FTCSSTSRSD
     SFLTFTPSIL SKSSSVSLDQ REEVPLTR