HOX4_ORYSJ
ID HOX4_ORYSJ Reviewed; 277 AA.
AC Q6K498; A0A0P0XNP7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Homeobox-leucine zipper protein HOX4;
DE AltName: Full=HD-ZIP protein HOX4;
DE AltName: Full=Homeodomain transcription factor HOX4;
DE AltName: Full=OsHox4;
GN Name=HOX4; OrderedLocusNames=Os09g0470500, LOC_Os09g29460;
GN ORFNames=OJ1595_D08.21;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [5]
RP FUNCTION, SUBUNIT, AND TISSUE SPECIFICITY.
RX PubMed=10732669; DOI=10.1007/pl00008671;
RA Meijer A.H., de Kam R.J., d'Erfurth I., Shen W.-B., Hoge J.H.C.;
RT "HD-Zip proteins of families I and II from rice: interactions and
RT functional properties.";
RL Mol. Gen. Genet. 263:12-21(2000).
RN [6]
RP TISSUE SPECIFICITY, INDUCTION, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17999151; DOI=10.1007/s11103-007-9255-7;
RA Agalou A., Purwantomo S., Oevernaes E., Johannesson H., Zhu X., Estiati A.,
RA de Kam R.J., Engstroem P., Slamet-Loedin I.H., Zhu Z., Wang M., Xiong L.,
RA Meijer A.H., Ouwerkerk P.B.F.;
RT "A genome-wide survey of HD-Zip genes in rice and analysis of drought-
RT responsive family members.";
RL Plant Mol. Biol. 66:87-103(2008).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=18049796; DOI=10.1007/s11103-007-9270-8;
RA Dai M., Hu Y., Ma Q., Zhao Y., Zhou D.-X.;
RT "Functional analysis of rice HOMEOBOX4 (Oshox4) gene reveals a negative
RT function in gibberellin responses.";
RL Plant Mol. Biol. 66:289-301(2008).
CC -!- FUNCTION: Probable transcription activator that binds to the DNA
CC sequence 5'-CAAT[AT]ATTG-3'. May be involved in the regulation of
CC gibberellin signaling. {ECO:0000269|PubMed:10732669,
CC ECO:0000269|PubMed:18049796}.
CC -!- SUBUNIT: Homodimer (Probable). May form a heterodimer with HOX5.
CC {ECO:0000269|PubMed:10732669, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:18049796}.
CC -!- TISSUE SPECIFICITY: Expressed in leaf and floral organ primordia,
CC floral meristems, embryonic axis and cells surrounding the vascular
CC bundles. Expressed in the vasculature of roots, stem, leaves and
CC spikelets, and in the vascular bundle of the scutellum in embryos.
CC {ECO:0000269|PubMed:10732669, ECO:0000269|PubMed:17999151,
CC ECO:0000269|PubMed:18049796}.
CC -!- INDUCTION: By gibberellin. Down-regulated in leaves by drought stress.
CC {ECO:0000269|PubMed:17999151, ECO:0000269|PubMed:18049796}.
CC -!- SIMILARITY: Belongs to the HD-ZIP homeobox family. Class I subfamily.
CC {ECO:0000305}.
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DR EMBL; AP005574; BAD22271.1; -; Genomic_DNA.
DR EMBL; AP008215; BAF25350.1; -; Genomic_DNA.
DR EMBL; AP014965; BAT08549.1; -; Genomic_DNA.
DR EMBL; AK099710; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015612509.1; XM_015757023.1.
DR AlphaFoldDB; Q6K498; -.
DR SMR; Q6K498; -.
DR STRING; 4530.OS09T0470500-01; -.
DR PaxDb; Q6K498; -.
DR PRIDE; Q6K498; -.
DR EnsemblPlants; Os09t0470500-01; Os09t0470500-01; Os09g0470500.
DR GeneID; 4347333; -.
DR Gramene; Os09t0470500-01; Os09t0470500-01; Os09g0470500.
DR KEGG; osa:4347333; -.
DR eggNOG; KOG0483; Eukaryota.
DR HOGENOM; CLU_060842_1_0_1; -.
DR InParanoid; Q6K498; -.
DR OMA; SWWTEPT; -.
DR OrthoDB; 1135658at2759; -.
DR Proteomes; UP000000763; Chromosome 9.
DR Proteomes; UP000059680; Chromosome 9.
DR Genevisible; Q6K498; OS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR045224; HDZip_class_I_plant.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR000047; HTH_motif.
DR InterPro; IPR003106; Leu_zip_homeo.
DR PANTHER; PTHR24326; PTHR24326; 1.
DR Pfam; PF02183; HALZ; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..277
FT /note="Homeobox-leucine zipper protein HOX4"
FT /id="PRO_0000331681"
FT DNA_BIND 48..107
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..150
FT /note="Leucine-zipper"
FT REGION 154..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 165
FT /note="A -> D (in Ref. 4; AK099710)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 277 AA; 29392 MW; 4C8D84A29981C639 CRC64;
MKRPGGAGGG GGSPSLVTMA NSSDDGYGGV GMEAEGDVEE EMMACGGGGE KKRRLSVEQV
RALERSFEVE NKLEPERKAR LARDLGLQPR QVAVWFQNRR ARWKTKQLER DYAALRHSYD
SLRLDHDALR RDKDALLAEI KELKAKLGDE EAAASFTSVK EEPAASDGPP AAGFGSSDSD
SSAVLNDVDA AGAAPAATDA LAPEACTFLG APPAAGAGAG AAAAASHEEV FFHGNFLKVE
EDETGFLDDD EPCGGFFADD QPPPLSSWWA EPTEHWN
