ID   HOXX_BRADU              Reviewed;         566 AA.
AC   P31907;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   28-FEB-2003, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Hydrogenase maturation factor HoxX;
GN   Name=hoxX; OrderedLocusNames=bll6926;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PRELIMINARY FUNCTION.
RC   STRAIN=CB1809;
RX   PubMed=8510650; DOI=10.1007/bf00281623;
RA   van Soom C., Verreth C., Sampaio M.J., Vanderleyden J.;
RT   "Identification of a potential transcriptional regulator of hydrogenase
RT   activity in free-living Bradyrhizobium japonicum strains.";
RL   Mol. Gen. Genet. 239:235-240(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
RN   [3]
RP   FUNCTION.
RX   PubMed=9171416; DOI=10.1128/jb.179.11.3676-3682.1997;
RA   Durmowicz M.C., Maier R.J.;
RT   "Roles of HoxX and HoxA in biosynthesis of hydrogenase in Bradyrhizobium
RT   japonicum.";
RL   J. Bacteriol. 179:3676-3682(1997).
CC   -!- FUNCTION: Involved in the post-translational processing of the
CC       hydrogenase large subunit. {ECO:0000269|PubMed:9171416}.
CC   -!- CAUTION: Was originally thought to be a sensor protein involved in the
CC       regulation of hydrogenase activity. {ECO:0000305|PubMed:8510650}.
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DR   EMBL; Z17373; CAA78990.1; -; Genomic_DNA.
DR   EMBL; BA000040; BAC52191.1; -; Genomic_DNA.
DR   PIR; S35231; S35231.
DR   RefSeq; NP_773566.1; NC_004463.1.
DR   RefSeq; WP_011089664.1; NZ_CP011360.1.
DR   AlphaFoldDB; P31907; -.
DR   SMR; P31907; -.
DR   STRING; 224911.27355207; -.
DR   EnsemblBacteria; BAC52191; BAC52191; BAC52191.
DR   GeneID; 64026682; -.
DR   KEGG; bja:bll6926; -.
DR   PATRIC; fig|224911.44.peg.6960; -.
DR   eggNOG; COG0223; Bacteria.
DR   eggNOG; COG1024; Bacteria.
DR   HOGENOM; CLU_008537_1_0_5; -.
DR   InParanoid; P31907; -.
DR   OMA; GFDPSYH; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0016742; F:hydroxymethyl-, formyl- and related transferase activity; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR005793; Formyl_trans_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR009188; NiFe-hyd_mat_HypX/HoxX.
DR   Pfam; PF00378; ECH_1; 1.
DR   Pfam; PF02911; Formyl_trans_C; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   PIRSF; PIRSF006787; Hydrgn_mat_HoxX; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   SUPFAM; SSF53328; SSF53328; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..566
FT                   /note="Hydrogenase maturation factor HoxX"
FT                   /id="PRO_0000209510"
FT   CONFLICT        113
FT                   /note="I -> V (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        115
FT                   /note="S -> A (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        123
FT                   /note="C -> R (in Ref. 1; CAA78990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        161
FT                   /note="A -> V (in Ref. 1; CAA78990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        187
FT                   /note="M -> A (in Ref. 1; CAA78990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        252
FT                   /note="K -> R (in Ref. 1; CAA78990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        345
FT                   /note="E -> G (in Ref. 1; CAA78990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        406
FT                   /note="I -> V (in Ref. 1; CAA78990)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        474
FT                   /note="Q -> R (in Ref. 1; CAA78990)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   566 AA;  61710 MW;  810E1D0DE8E2E7C8 CRC64;
     MRILLLSHSF NSLTQRLHVE LRERGHEVSV ELDIHADVTR ESVALHRPDL VIAPFLKRAI
     PDDVWRSVRC LVVHPGPPGD RGPAALDWAV LEGVAEWGVT VLQADGEFDA GPIWSFRSFP
     MRCAAKSSIY RNELTSCAVA AVLEAVAAIE AGQAAPQPMQ AGDPRIRVRG PCRQADRTID
     WQHDSTMTVL RKINSADGMP GLVDSLFFQE VRLFDAHEAH DISGVPGTVI AQCEGALARA
     TVDGAVWIGH VKRLAPKSLK LPAAKVFAAE AAYLPHRPGC GYAPIRYREH GEVGELAFSF
     YNGAMATGDC EALLGAYRAA LERPTRVLLL TGGPDYWSNG IHLAEIEAAE SAADESWRNI
     NAIDDLARAI IETTDRLVVS VIRGNAGAGG VFLSLAADEV WASDQIILNP HYKDMGNLYG
     SEYWTYLLPR RAGAANATRI TQCRLPMGVA EARRLAIVDR VLSGEALADA SLVQSGAAMA
     SDAGFAARLA AKQQRRAADE AEKPLQSYRD EELRRMKLNF YGFDPSYHVA RYNFIHKVPK
     SRTPLTIAGH RIRRAPGRPV GMAVSS