ID   HOY1_YARLI              Reviewed;         509 AA.
AC   Q99160; Q6CGK8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Homeobox protein HOY1;
GN   Name=HOY1; OrderedLocusNames=YALI0A18469g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RA   Torres-Guzmon J.;
RL   Thesis (1994), University of Salamanca, Spain.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; Z34956; CAA84415.1; -; Genomic_DNA.
DR   EMBL; CR382127; CAG84136.1; -; Genomic_DNA.
DR   RefSeq; XP_500204.1; XM_500204.1.
DR   AlphaFoldDB; Q99160; -.
DR   SMR; Q99160; -.
DR   STRING; 4952.CAG84136; -.
DR   EnsemblFungi; CAG84136; CAG84136; YALI0_A18469g.
DR   GeneID; 2906050; -.
DR   KEGG; yli:YALI0A18469g; -.
DR   VEuPathDB; FungiDB:YALI0_A18469g; -.
DR   HOGENOM; CLU_535517_0_0_1; -.
DR   InParanoid; Q99160; -.
DR   OMA; CEYLTIG; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..509
FT                   /note="Homeobox protein HOY1"
FT                   /id="PRO_0000049139"
FT   DNA_BIND        16..75
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        260
FT                   /note="L -> F (in Ref. 1; CAA84415)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   509 AA;  55886 MW;  FE69298358C76715 CRC64;
     MDKKRSKKST LTQQQRNNKR QRANAQQLDV LRHEYRLCAT PDAATRRRIS ALIDMTERSV
     QIWFQNTRAK QKKAMRGRES REDDFDDGLA DVSVDDVSVD DVSMTADVIN SPVDVIHHRT
     DVSSSADMLH HFGADLVTTP IQTHFNHLLA TPPTSSSSSH VTTVDSPASS ITDFSTLGHM
     TPNLTPTTPH HVTLPPIFFP TLSLTIGNWR RLSPQLSLAY YPSTDTMLYH MTSEKTQFRM
     QFPFSAIEEI HVSRNPNDTL GALNLTLNCS PSFSIQTPKA PGRWVGCHDF SEGKQASNVT
     THVCNGPATV LQQQLSRVFA LRSNHVNGHV SRRRLADVIG SSDIIGSADV MGTVAVDTSN
     HMISSHVGDF ELSVTSHCEP SHMIEPTPTP TPVANHHHHR SADSVAHVTN PSGHVTNHNH
     LSDPAANLTS TILGNVTPGH TTPVLDDGFE LGHVTDINDL VSVAQLLPNH VTEAELASNC
     HMIANNAFTL DPSTPLSPFS GTLDYLEYY