ID   HP1B3_CHICK             Reviewed;         559 AA.
AC   Q5ZM33;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Heterochromatin protein 1-binding protein 3;
GN   Name=HP1BP3; ORFNames=RCJMB04_3f4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of heterochromatin that maintains heterochromatin
CC       integrity during G1/S progression and regulates the duration of G1
CC       phase to critically influence cell proliferative capacity.
CC       {ECO:0000250|UniProtKB:Q5SSJ5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5SSJ5}.
CC       Chromosome {ECO:0000250|UniProtKB:Q5SSJ5}.
CC   -!- DOMAIN: A central region that included the first H15 (linker histone
CC       H1/H5 globular) domain binds at the entry/exit site of the nucleosomal
CC       DNA. {ECO:0000250|UniProtKB:Q5SSJ5}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ719551; CAG31210.1; -; mRNA.
DR   RefSeq; NP_001006560.1; NM_001006560.1.
DR   AlphaFoldDB; Q5ZM33; -.
DR   SMR; Q5ZM33; -.
DR   STRING; 9031.ENSGALP00000016363; -.
DR   PaxDb; Q5ZM33; -.
DR   GeneID; 425543; -.
DR   KEGG; gga:425543; -.
DR   CTD; 50809; -.
DR   VEuPathDB; HostDB:geneid_425543; -.
DR   eggNOG; KOG4012; Eukaryota.
DR   InParanoid; Q5ZM33; -.
DR   OrthoDB; 903215at2759; -.
DR   PhylomeDB; Q5ZM33; -.
DR   PRO; PR:Q5ZM33; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR   GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   GO; GO:0070828; P:heterochromatin organization; IBA:GO_Central.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00073; H15; 1.
DR   Gene3D; 1.10.10.10; -; 3.
DR   InterPro; IPR005818; Histone_H1/H5_H15.
DR   InterPro; IPR033061; HP1BP3.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR15832:SF1; PTHR15832:SF1; 1.
DR   Pfam; PF00538; Linker_histone; 3.
DR   SMART; SM00526; H15; 3.
DR   SUPFAM; SSF46785; SSF46785; 3.
DR   PROSITE; PS51504; H15; 3.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..559
FT                   /note="Heterochromatin protein 1-binding protein 3"
FT                   /id="PRO_0000339645"
FT   DOMAIN          158..233
FT                   /note="H15 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   DOMAIN          256..331
FT                   /note="H15 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   DOMAIN          339..414
FT                   /note="H15 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00837"
FT   REGION          1..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          421..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           256..260
FT                   /note="PxVxL motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SSJ5"
FT   COMPBIAS        28..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..457
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  61851 MW;  65CABB11119B4F58 CRC64;
     MATDLSEAEP VHHKALPLLT GTQLIHTDKL SEKAEDDTMP IRRSVNSSRE TPPKSKPAEG
     GEEVKADAEA TSEESASAGE EQENETLPAA APSEAEQPKE PENEEKGETK SSVETKKDDK
     DQSKEKEKKV KKTIPAWATL SASQLARAQK QTQMAATSRP KMDAILTEAI KACFQKSGAS
     VVAIRKYIIH KYPSLELERR GYLLKQALKR ELERGIIRQV KGKGASGSFV VVSNAGKTVQ
     KARDRKKSTS VSTPEQQVKL EDILPLAFTR LCEPKEASYS LIKKYVSQYY PKLKVDIRPQ
     LLKNALQRAV EKGQLEQITG KGASGTFQLK KSGEKPLLGG TLMEDAILSA IAAMNEPKTC
     STTALKKYIL ENHPGTNSNF QVHLLKRTLQ RCEKNGWLEQ ISGKGFSGTF QLCFPYYPSP
     DVLYPEKQQD EDSEESQEEE EEESEEEEES EEEESEEEEP PPKKRMQKRP PPKSRSRAPP
     MKRRESKPKP RKTPAAHQGK AKPPPKVKTP VKKAKPAAPA IKKPSGGSSS KKPTASGRKE
     VKPSAKGKSA MRKSLRAKK