ID   HP252_BOVIN             Reviewed;         215 AA.
AC   Q2KIU3;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Protein HP-25 homolog 2;
DE   Flags: Precursor;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Wong G.W.;
RT   "Identification and characterization of three novel C1q/TNF family members
RT   that are orthologs of the siberian chipmunk hibernating proteins HP-20, HP-
RT   25, and HP-27.";
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR   EMBL; FJ645736; ACV32360.1; -; mRNA.
DR   EMBL; BC112508; AAI12509.1; -; mRNA.
DR   RefSeq; NP_001039544.1; NM_001046079.1.
DR   AlphaFoldDB; Q2KIU3; -.
DR   SMR; Q2KIU3; -.
DR   STRING; 9913.ENSBTAP00000024695; -.
DR   PaxDb; Q2KIU3; -.
DR   PeptideAtlas; Q2KIU3; -.
DR   PRIDE; Q2KIU3; -.
DR   Ensembl; ENSBTAT00000024695; ENSBTAP00000024695; ENSBTAG00000018556.
DR   GeneID; 511239; -.
DR   KEGG; bta:511239; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018556; -.
DR   eggNOG; ENOG502SK5K; Eukaryota.
DR   GeneTree; ENSGT00900000141239; -.
DR   HOGENOM; CLU_001074_0_2_1; -.
DR   InParanoid; Q2KIU3; -.
DR   OMA; PGDTESC; -.
DR   OrthoDB; 1258047at2759; -.
DR   TreeFam; TF329591; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000018556; Expressed in liver and 24 other tissues.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.120.40; -; 1.
DR   InterPro; IPR001073; C1q_dom.
DR   InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR   Pfam; PF00386; C1q; 1.
DR   PRINTS; PR00007; COMPLEMNTC1Q.
DR   SMART; SM00110; C1Q; 1.
DR   SUPFAM; SSF49842; SSF49842; 1.
DR   PROSITE; PS50871; C1Q; 1.
PE   2: Evidence at transcript level;
KW   Collagen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..215
FT                   /note="Protein HP-25 homolog 2"
FT                   /id="PRO_0000399906"
FT   DOMAIN          43..76
FT                   /note="Collagen-like"
FT   DOMAIN          82..215
FT                   /note="C1q"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00368"
FT   REGION          35..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..70
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  22911 MW;  C4850503A6EC5E74 CRC64;
     MPGRGGQSLS MVCVDVWILA LSVLSVMADA TSVPVTESCD SQGPPGLPGP PGLPGPPGPP
     GPPGPPGLRG PTGIPGDIES CLSPPKSAFA VKMNDPLPAP SQPIVFKEAL HNDQDHFNLT
     TGVFTCTIPG VYRFGFDIEL FQHAVKLGLM KNDTQILEKE SKAKDNYRHL SGNVVLQLTL
     GDRVWLESKL DTTETEKGPI QSMFFGYLLY GNYPG