HP301_ARATH
ID HP301_ARATH Reviewed; 261 AA.
AC Q9SCK3;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Chloroplastic import inner membrane translocase subunit HP30-1 {ECO:0000305};
DE AltName: Full=Hypothetical inner plastid envelope protein of 30 kDa 1 {ECO:0000303|PubMed:24248378};
DE Short=AtHP30-1 {ECO:0000303|PubMed:24248378};
DE Short=Hypothetical protein 30 {ECO:0000303|PubMed:24248378};
GN Name=HP30-1 {ECO:0000303|PubMed:24248378};
GN OrderedLocusNames=At3g49560 {ECO:0000312|Araport:AT3G49560};
GN ORFNames=T9C5.150 {ECO:0000312|EMBL:CAB62460.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND GENE FAMILY.
RX PubMed=17098851; DOI=10.1104/pp.106.090688;
RA Murcha M.W., Elhafez D., Lister R., Tonti-Filippini J., Baumgartner M.,
RA Philippar K., Carrie C., Mokranjac D., Soll J., Whelan J.;
RT "Characterization of the preprotein and amino acid transporter gene family
RT in Arabidopsis.";
RL Plant Physiol. 143:199-212(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION.
RX PubMed=15901827; DOI=10.1074/mcp.m500018-mcp200;
RA von Zychlinski A., Kleffmann T., Krishnamurthy N., Sjoelander K.,
RA Baginsky S., Gruissem W.;
RT "Proteome analysis of the rice etioplast: metabolic and regulatory networks
RT and novel protein functions.";
RL Mol. Cell. Proteomics 4:1072-1084(2005).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP CEQORH.
RC STRAIN=cv. Columbia;
RX PubMed=24248378; DOI=10.1073/pnas.1319648110;
RA Rossig C., Reinbothe C., Gray J., Valdes O., von Wettstein D.,
RA Reinbothe S.;
RT "Three proteins mediate import of transit sequence-less precursors into the
RT inner envelope of chloroplasts in Arabidopsis thaliana.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19962-19967(2013).
CC -!- FUNCTION: Together with HP30-2 and HP20, triggers the import and
CC insertion of transit sequence-less multi-pass transmembrane proteins
CC (e.g. CEQORH) into the chloroplastic inner membrane.
CC {ECO:0000269|PubMed:24248378}.
CC -!- SUBUNIT: Probable component of a protein-conducting channel made of
CC HP30-1, HP30-2 and HP20 that mediates the import of transit sequence-
CC less proteins into the chloroplastic inner membrane. Interacts with
CC CEQORH. {ECO:0000269|PubMed:24248378}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast inner membrane
CC {ECO:0000269|PubMed:17098851, ECO:0000269|PubMed:24248378}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Plants lacking both HP30-1 and HP30-2 are yellow
CC to pale-green and impaired import of CEQORH in chloroplast inner
CC membranes. {ECO:0000269|PubMed:24248378}.
CC -!- SIMILARITY: Belongs to the Tim17/Tim22/Tim23 family. {ECO:0000305}.
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DR EMBL; DQ405266; ABD64055.1; -; mRNA.
DR EMBL; AL132964; CAB62460.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78557.1; -; Genomic_DNA.
DR EMBL; AF360191; AAK25901.1; -; mRNA.
DR EMBL; BT001951; AAN71950.1; -; mRNA.
DR EMBL; AY085551; AAM62775.1; -; mRNA.
DR PIR; T46233; T46233.
DR RefSeq; NP_190525.1; NM_114816.4.
DR AlphaFoldDB; Q9SCK3; -.
DR SMR; Q9SCK3; -.
DR STRING; 3702.AT3G49560.1; -.
DR PaxDb; Q9SCK3; -.
DR PRIDE; Q9SCK3; -.
DR ProteomicsDB; 232149; -.
DR DNASU; 824118; -.
DR EnsemblPlants; AT3G49560.1; AT3G49560.1; AT3G49560.
DR GeneID; 824118; -.
DR Gramene; AT3G49560.1; AT3G49560.1; AT3G49560.
DR KEGG; ath:AT3G49560; -.
DR Araport; AT3G49560; -.
DR TAIR; locus:2114723; AT3G49560.
DR eggNOG; ENOG502QPIB; Eukaryota.
DR HOGENOM; CLU_072970_0_0_1; -.
DR InParanoid; Q9SCK3; -.
DR OMA; RSGGEMM; -.
DR OrthoDB; 1451194at2759; -.
DR PhylomeDB; Q9SCK3; -.
DR PRO; PR:Q9SCK3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SCK3; baseline and differential.
DR GO; GO:0009507; C:chloroplast; IDA:UniProtKB.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0009706; C:chloroplast inner membrane; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0043621; F:protein self-association; IPI:TAIR.
DR GO; GO:0008320; F:protein transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IGI:TAIR.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IEA:InterPro.
DR GO; GO:0045036; P:protein targeting to chloroplast; IMP:UniProtKB.
DR GO; GO:0016031; P:tRNA import into mitochondrion; IGI:TAIR.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR039175; TIM22.
DR PANTHER; PTHR14110; PTHR14110; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Membrane; Plastid; Plastid inner membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..261
FT /note="Chloroplastic import inner membrane translocase
FT subunit HP30-1"
FT /id="PRO_0000443724"
FT TRANSMEM 59..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..180
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 261 AA; 27982 MW; E050A478D1B02A7C CRC64;
MVVGGGGEGD QKRSSGEMMA MASLFNDQQN PIQQFQVKFK EVETNFKTWL SKQSIPVEAA
VVSTMSGVQG AFIGGLMGTL SPEMPQAGVD PQAIASMKQA QALVGGPWVQ ARNFAAITGV
NAGIASVMKR IRGKEDIESA VVAALGSGFA YSLVSQGLQG QPMNAITTAA GFAVFQGVFF
KLGERFSKPS TEDPFFTRGR TMLVKLGLEK YEKNFKKGLL TDPTLPLLTD SALKDANIPP
GPRLMILDHI QRDPEIKGKR K