ID   HP4_ELSFA               Reviewed;         122 AA.
AC   B1A0U8;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Elsinochromes biosynthesis cluster protein HP4 {ECO:0000303|PubMed:18957608};
GN   Name=HP4 {ECO:0000303|PubMed:18957608};
OS   Elsinoe fawcettii (Citrus scab fungus) (Sphaceloma fawcettii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Myriangiales; Elsinoaceae; Elsinoe.
OX   NCBI_TaxID=40997;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, FUNCTION, AND INDUCTION.
RX   PubMed=18957608; DOI=10.1099/mic.0.2008/019414-0;
RA   Chung K.R., Liao H.L.;
RT   "Determination of a transcriptional regulator-like gene involved in
RT   biosynthesis of elsinochrome phytotoxin by the citrus scab fungus, Elsinoe
RT   fawcettii.";
RL   Microbiology 154:3556-3566(2008).
RN   [2]
RP   REVIEW.
RX   PubMed=21199563; DOI=10.1111/j.1364-3703.2010.00663.x;
RA   Chung K.R.;
RT   "Elsinoe fawcettii and Elsinoe australis: the fungal pathogens causing
RT   citrus scab.";
RL   Mol. Plant Pathol. 12:123-135(2011).
CC   -!- FUNCTION: Part of the gene cluster that mediates the biosynthesis of
CC       elsinochromes, pigments consisting of at least four interconvertible
CC       tautomers (A, B, C and D) that have a core phenolic quinone to which
CC       various side chains are attached and which play an important role in
CC       fungal pathogenesis (PubMed:18957608). The non-reducing polyketide
CC       synthase PKS1 was proposed to iteratively catalyze decarboxylation
CC       between acetyl-CoA and malonyl-CoA subunits for polyketide chain
CC       elongation. The released polyketide undergoes cyclization to form an
CC       aromatic ring, and proceeds via serial modification steps to produce
CC       the heptaketide back- bone of elsinochrome. As elsinochrome has a
CC       symmetrical structure, two identical heptaketides are fused to form a
CC       core 1,2-dihydrobenzo-perylene ring structure, which can then be
CC       successively modified to produce the various derivatives of
CC       elsinochrome. Some of these reactions may be cooperatively carried out,
CC       at least in part, by the products of RDT1, OXR1 and PKS1. PRF1,
CC       embedded within the elsinochrome cluster possibly functions to
CC       stabilize some of the biosynthetic enzymes required for elsinochrome
CC       production. As prefoldin is a hexamer containing 2 a and 4 b subunits,
CC       additional prefoldin subunits, whose coding genes may not immediately
CC       link to the elsinochrome biosynthetic gene cluster, are required to
CC       fulfill the chaperone function. In addition, no methyltransferase-
CC       coding gene exists within the biosynthetic gene cluster, even though
CC       elsinochrome has four methyl groups at positions C3, C7, C8 and C12.
CC       Apparently, the identified gene cluster does not contain the entire
CC       entourage of genes responsible for elsinochrome biosynthesis. Once
CC       elsinochrome is synthesized, it must be exported outside the fungal
CC       cells, which is probably accomplished by the ECT1 transporter, to avoid
CC       toxicity (PubMed:21199563). {ECO:0000269|PubMed:18957608,
CC       ECO:0000303|PubMed:21199563}.
CC   -!- INDUCTION: Expression is up-regulated during nitrogen starvation.
CC       {ECO:0000269|PubMed:18957608}.
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DR   EMBL; EU414202; ABZ82012.1; -; Genomic_DNA.
DR   AlphaFoldDB; B1A0U8; -.
PE   2: Evidence at transcript level;
FT   CHAIN           1..122
FT                   /note="Elsinochromes biosynthesis cluster protein HP4"
FT                   /id="PRO_0000445826"
SQ   SEQUENCE   122 AA;  13822 MW;  375459C7BA9E5006 CRC64;
     MDRSQALYYP WDSFCLLSRC SIFILSTTLE DSRTLLSHLG LQNPHEVQGT FVPEARVPGV
     RLEATAGHQS LSEPSGWVYY RHKHSDLVDP ADLHLQGASY RRSTIRSYLM VKKVLYLVSS
     AP