ID   HPAA1_HELPX             Reviewed;         260 AA.
AC   Q48264;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Neuraminyllactose-binding hemagglutinin;
DE   AltName: Full=Flagellar sheath adhesin;
DE   AltName: Full=N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunit;
DE            Short=NLBH;
DE   Flags: Precursor;
GN   Name=hpaA;
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=8826;
RX   PubMed=7678592; DOI=10.1128/jb.175.3.674-683.1993;
RA   Evans D.G., Karjalainen T.K., Evans D.J. Jr., Graham D.Y., Lee C.-H.;
RT   "Cloning, nucleotide sequence, and expression of a gene encoding an adhesin
RT   subunit protein of Helicobacter pylori.";
RL   J. Bacteriol. 175:674-683(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-166.
RC   STRAIN=8826;
RX   PubMed=7557486; DOI=10.1016/0378-1119(95)00404-t;
RA   Evans D.G., Lampert H.C., Nakano H., Eaton K.A., Burnens A.P.,
RA   Bronsdon M.A., Evans D.J. Jr.;
RT   "Genetic evidence for host specificity in the adhesin-encoding genes hxaA
RT   of Helicobacter acinonyx, hnaA of H. nemestrinae and hpaA of H. pylori.";
RL   Gene 163:97-102(1995).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- PTM: The N-terminus is blocked.
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DR   EMBL; X61574; CAA43773.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q48264; -.
DR   SMR; Q48264; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.160.180; -; 1.
DR   InterPro; IPR007876; NeuraminylLac-bd_hemagglutn.
DR   InterPro; IPR038531; NeuraminylLac-bd_hemagglutn_sf.
DR   Pfam; PF05211; NLBH; 1.
DR   PIRSF; PIRSF019714; Neuraminyllac-bd_haemagglutn; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           28..260
FT                   /note="Neuraminyllactose-binding hemagglutinin"
FT                   /id="PRO_0000018101"
FT   REGION          134..139
FT                   /note="N-acetyl-neuraminyl-alpha(2,3)-lactose binding
FT                   motif"
FT                   /evidence="ECO:0000255"
FT   LIPID           28
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           28
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   260 AA;  29167 MW;  22489598065E7B14 CRC64;
     MKTNGHFKDF AWKKCLLGTS VVALLVGCSP HIIETNEVAL KLNYHPASEK VQALDEKILL
     LKPAFQYSDN IAKEYENKFK NQTTLKVEEI LQNQGYKVIN VDSSDKDDFS FAQKKEGYLA
     VAMIGEIVLR PDPKRTIQKK SEPGLLFSTG LDKMEGVLIP AGFVKVTILE PMSGESLDSF
     TMDLSELDIQ EKFLKTTHSS HSGGLVSTMV KGTDNSNDAI KSALNKIFAS IMQEMDKKLT
     QRNLESYQKD AKELKNKRNR