HPAA2_HELPX
ID HPAA2_HELPX Reviewed; 260 AA.
AC Q48254;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Neuraminyllactose-binding hemagglutinin;
DE AltName: Full=Flagellar sheath adhesin;
DE AltName: Full=N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunit;
DE Short=NLBH;
DE Flags: Precursor;
GN Name=hpaA;
OS Helicobacter pylori (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=210;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=DSM 4867 / CCUG 17874 / NCTC 11638;
RX PubMed=7592366; DOI=10.1128/jb.177.21.6049-6057.1995;
RA O'Toole P.W., Janzon L., Doig P., Huang J., Kostrzynska M., Trust T.J.;
RT "The putative neuraminyllactose-binding hemagglutinin HpaA of Helicobacter
RT pylori CCUG 17874 is a lipoprotein.";
RL J. Bacteriol. 177:6049-6057(1995).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}.
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DR EMBL; U35455; AAA79096.1; -; Genomic_DNA.
DR AlphaFoldDB; Q48254; -.
DR SMR; Q48254; -.
DR STRING; 1345592.CBOM010000011_gene1007; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.30.160.180; -; 1.
DR InterPro; IPR007876; NeuraminylLac-bd_hemagglutn.
DR InterPro; IPR038531; NeuraminylLac-bd_hemagglutn_sf.
DR Pfam; PF05211; NLBH; 1.
DR PIRSF; PIRSF019714; Neuraminyllac-bd_haemagglutn; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 28..260
FT /note="Neuraminyllactose-binding hemagglutinin"
FT /id="PRO_0000018102"
FT REGION 134..139
FT /note="N-acetyl-neuraminyl-alpha(2,3)-lactose binding
FT motif"
FT /evidence="ECO:0000255"
FT LIPID 28
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000305"
FT LIPID 28
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 29003 MW; 676DDA952E99E03C CRC64;
MKTNGHFKDF AWKKCLLGAS VGALLVGCSP HIIETNEVAL KLNYHPASEK VQALDEKILL
LRPAFQYSDN IAKEYENKFK NQTVLKVEQI LQNQGYKVIN VDSSDKDDFS FAQKKEGYLA
VAMNGEIVLR PDPKRTIQKK SEPGLLFSTG LDKMEGVLIP AGFVKVTILE PMSGESLDSF
TMDLSELDIQ EKFLKTTHSS HSGGLVSTMV KGTDNSNDAI KSALNKIFGS IMQEIDKKLT
QKNLESYQKD AKELKGKRNR