ID   HPAB1_PSESH             Reviewed;         539 AA.
AC   Q9RBW3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Effector protein hopAB1;
DE   AltName: Full=Protein virPphA;
GN   Name=hopAB1; Synonyms=virPphA;
OS   Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv.
OS   phaseolicola).
OG   Plasmid pAV511, and Plasmid pAV520.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=1449B / Race 7; PLASMID=pAV511;
RX   PubMed=10485919; DOI=10.1073/pnas.96.19.10875;
RA   Jackson R.W., Athanassopoulos E., Tsiamis G., Mansfield J.W., Sesma A.,
RA   Arnold D.L., Gibbon M.J., Murillo J., Taylor J.D., Vivian A.;
RT   "Identification of a pathogenicity island, which contains genes for
RT   virulence and avirulence, on a large native plasmid in the bean pathogen
RT   Pseudomonas syringae pathovar phaseolicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:10875-10880(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1449B / Race 7; PLASMID=pAV520;
RA   Tsiamis G., Mansfield J.W.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RC   STRAIN=1449B / Race 7; PLASMID=pAV520;
RX   AGRICOLA=IND23295115; DOI=10.1046/j.1364-3703.2002.00121.x;
RA   Jackson R.W., Mansfield J.W., Ammouneh H., Dutton L.C., Wharton B.,
RA   Ortiz-Barredo A., Arnold D.L., Tsiamis G., Sesma A., Butcher D., Boch J.,
RA   Kim Y.J., Martin G.B., Tegli S., Murillo J., Vivian A.;
RT   "Location and activity of members of a family of virPphA homologues in
RT   pathovars of Pseudomonas syringae and P.savastanoi.";
RL   Mol. Plant Pathol. 3:205-216(2002).
RN   [4]
RP   SUBCELLULAR LOCATION, AND INDUCTION BY HRPL.
RC   STRAIN=1449B / Race 7;
RX   PubMed=15553250; DOI=10.1094/mpmi.2004.17.11.1250;
RA   Thwaites R., Spanu P.D., Panopoulos N.J., Stevens C., Mansfield J.W.;
RT   "Transcriptional regulation of components of the type III secretion system
RT   and effectors in Pseudomonas syringae pv. phaseolicola.";
RL   Mol. Plant Microbe Interact. 17:1250-1258(2004).
CC   -!- FUNCTION: Effector protein that plays different roles depending on the
CC       species and plant cultivars that interact with the pathogen. Acts as a
CC       virulence determinant by enhancing the development of disease symptoms
CC       and bacterial growth. Acts as an avirulence factor by eliciting
CC       hypersensitive response (HR) and plant resistance.
CC       {ECO:0000269|PubMed:10485919, ECO:0000269|Ref.3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15553250}.
CC       Note=Secreted via type III secretion system (TTSS).
CC   -!- INDUCTION: Transcriptionally induced by HrpL.
CC       {ECO:0000269|PubMed:15553250}.
CC   -!- SIMILARITY: Belongs to the HopAB family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF141883; AAD47203.1; -; Genomic_DNA.
DR   EMBL; AY603426; AAV68746.1; -; Genomic_DNA.
DR   RefSeq; WP_011282445.1; NZ_RBUR01000344.1.
DR   AlphaFoldDB; Q9RBW3; -.
DR   BMRB; Q9RBW3; -.
DR   SMR; Q9RBW3; -.
DR   DIP; DIP-61109N; -.
DR   IntAct; Q9RBW3; 1.
DR   PHI-base; PHI:989; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0034053; P:modulation by symbiont of host defense-related programmed cell death; IEA:UniProtKB-KW.
DR   CDD; cd12803; HopAB_BID; 1.
DR   CDD; cd12802; HopAB_PID; 1.
DR   Gene3D; 1.20.1280.220; -; 1.
DR   Gene3D; 3.30.40.110; -; 1.
DR   InterPro; IPR015133; E3_ubiquit_lig_AvrPtoB.
DR   InterPro; IPR031759; HopAB_BAK-bd.
DR   InterPro; IPR038342; HopAB_BAK-bd_sf.
DR   InterPro; IPR038448; HopAB_E3_ubiquit_lig_sf.
DR   InterPro; IPR033743; HopAB_PID.
DR   Pfam; PF09046; AvrPtoB-E3_ubiq; 1.
DR   Pfam; PF16847; AvrPtoB_bdg; 1.
PE   2: Evidence at transcript level;
KW   Hypersensitive response elicitation; Plasmid; Secreted; Virulence.
FT   CHAIN           1..539
FT                   /note="Effector protein hopAB1"
FT                   /id="PRO_0000236789"
FT   REGION          1..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          315..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..214
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  59575 MW;  9755A3F3770319C6 CRC64;
     MPGINGAGPS NFFWQWRTDG EPVTEREHDS SRSASSANSP ELPPPASPAE SGRQRLLRSS
     ALSRQTREWL EATPARVQGA TPPAEARQSP EAQQAERIVQ ELVRGGADLN NVRTMLRNVM
     DNNAVAFSRV ERDILLQHFP NMPMTGISSD SVLANELRQR LRQTVRQQRI QSSTPARLAD
     SSSGSSQRSL IGRSTMLMTP GRSSSSSAAA SRTSVDRHPQ GLDLESARLA SAARHNHSAN
     QTNEALRRLT QEGVDMERLR TSLGRYIMSL EPLPPDLRRA LESVGINPFI PEELSLVDHP
     VLNFSAALNR MLASRQTTTN SPELPPLASS AESGRRRLLR SPPLLSGQRE WIEQSMRQEA
     EPQSSRLNRA VRLAVMPPQN ENEDNVAYAI RLRRLNPGAD VSRVVASFIT DPAARQQVVN
     DIRAALDIAP QFSQLRTISK ADAESEELGF RDAADHPDNA TSCLFGEELS LSNPDQQVIG
     LAVNPTDKPQ PYSQEVNKAL TFMDMKKLAQ YLADKPEHPL NRQRLDAKNI AKYAFKIVP