ID   HPAC_SALTI              Reviewed;         170 AA.
AC   Q8Z7Q5;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=4-hydroxyphenylacetate 3-monooxygenase reductase component;
DE            EC=1.5.1.36;
DE   AltName: Full=4-HPA 3-monooxygenase small component;
DE   AltName: Full=Flavin:NADH reductase;
GN   Name=hpaC; OrderedLocusNames=STY1130, t1821;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Catalyzes the reduction of free flavins (FMN, FAD and
CC       riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the
CC       large HpaB component or to other electron acceptors such as cytochrome
CC       c and Fe(3+) ion (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:31303, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:60531, ChEBI:CHEBI:62787; EC=1.5.1.36;
CC   -!- PATHWAY: Aromatic compound metabolism; 4-hydroxyphenylacetate
CC       degradation; pyruvate and succinate semialdehyde from 4-
CC       hydroxyphenylacetate: step 1/7.
CC   -!- SUBUNIT: Homodimer (Probable). 4-HPA 3-monooxygenase consists of a
CC       reductase component HpaC and an oxygenase component HpaB (By
CC       similarity). {ECO:0000250, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the non-flavoprotein flavin reductase family.
CC       HpaC subfamily. {ECO:0000305}.
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DR   EMBL; AL513382; CAD08224.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO69442.1; -; Genomic_DNA.
DR   RefSeq; NP_455595.1; NC_003198.1.
DR   RefSeq; WP_001195559.1; NZ_QXGZ01000060.1.
DR   AlphaFoldDB; Q8Z7Q5; -.
DR   SMR; Q8Z7Q5; -.
DR   STRING; 220341.16502272; -.
DR   EnsemblBacteria; AAO69442; AAO69442; t1821.
DR   KEGG; stt:t1821; -.
DR   KEGG; sty:STY1130; -.
DR   PATRIC; fig|220341.7.peg.1132; -.
DR   eggNOG; COG1853; Bacteria.
DR   HOGENOM; CLU_059021_2_2_6; -.
DR   OMA; CINVLPA; -.
DR   UniPathway; UPA00208; UER00416.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0036382; F:flavin reductase (NADH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0042537; P:benzene-containing compound metabolic process; IEA:InterPro.
DR   Gene3D; 2.30.110.10; -; 1.
DR   InterPro; IPR002563; Flavin_Rdtase-like_dom.
DR   InterPro; IPR011982; HPA_mOase_red.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   Pfam; PF01613; Flavin_Reduct; 1.
DR   SMART; SM00903; Flavin_Reduct; 1.
DR   TIGRFAMs; TIGR02296; HpaC; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Flavoprotein; FMN; NAD; Oxidoreductase.
FT   CHAIN           1..170
FT                   /note="4-hydroxyphenylacetate 3-monooxygenase reductase
FT                   component"
FT                   /id="PRO_0000085535"
FT   CONFLICT        87
FT                   /note="V -> A (in Ref. 2; AAO69442)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   170 AA;  18553 MW;  11F22B6A9B9FFDA3 CRC64;
     MQVDEQRLRF RDAMASLAAA VNIVTTAGHA GRCGITATAV CSVTDTPPSV MVCINANSAM
     NPVFQGNGRL CINVLNHEQE LMARHFVGMT GMAMEERFHQ PCWQNGPLGQ PVLNGALASL
     EGEISEVQTI GTHLVYLVAI KNIILSQEGH GLIYFKRRFH PVRLEMEAPV