ID   HPAC_SALTY              Reviewed;         170 AA.
AC   Q8ZQ51;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=4-hydroxyphenylacetate 3-monooxygenase reductase component;
DE            EC=1.5.1.36;
DE   AltName: Full=4-HPA 3-monooxygenase small component;
DE   AltName: Full=Flavin:NADH reductase;
GN   Name=hpaC; OrderedLocusNames=STM1098;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes the reduction of free flavins (FMN, FAD and
CC       riboflavin) by NADH. Subsequently, the reduced flavins diffuse to the
CC       large HpaB component or to other electron acceptors such as cytochrome
CC       c and Fe(3+) ion (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a reduced flavin + NAD(+) = an oxidized flavin + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:31303, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:60531, ChEBI:CHEBI:62787; EC=1.5.1.36;
CC   -!- PATHWAY: Aromatic compound metabolism; 4-hydroxyphenylacetate
CC       degradation; pyruvate and succinate semialdehyde from 4-
CC       hydroxyphenylacetate: step 1/7.
CC   -!- SUBUNIT: Homodimer. 4-HPA 3-monooxygenase consists of a reductase
CC       component HpaC and an oxygenase component HpaB (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the non-flavoprotein flavin reductase family.
CC       HpaC subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL20030.1; -; Genomic_DNA.
DR   RefSeq; NP_460071.1; NC_003197.2.
DR   RefSeq; WP_001195556.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZQ51; -.
DR   SMR; Q8ZQ51; -.
DR   STRING; 99287.STM1098; -.
DR   PaxDb; Q8ZQ51; -.
DR   EnsemblBacteria; AAL20030; AAL20030; STM1098.
DR   GeneID; 1252616; -.
DR   KEGG; stm:STM1098; -.
DR   PATRIC; fig|99287.12.peg.1162; -.
DR   HOGENOM; CLU_059021_2_2_6; -.
DR   OMA; CINVLPA; -.
DR   PhylomeDB; Q8ZQ51; -.
DR   BioCyc; SENT99287:STM1098-MON; -.
DR   UniPathway; UPA00208; UER00416.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0036382; F:flavin reductase (NADH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR   GO; GO:0042602; F:riboflavin reductase (NADPH) activity; IBA:GO_Central.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0042537; P:benzene-containing compound metabolic process; IEA:InterPro.
DR   GO; GO:0006208; P:pyrimidine nucleobase catabolic process; IBA:GO_Central.
DR   Gene3D; 2.30.110.10; -; 1.
DR   InterPro; IPR002563; Flavin_Rdtase-like_dom.
DR   InterPro; IPR011982; HPA_mOase_red.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   Pfam; PF01613; Flavin_Reduct; 1.
DR   SMART; SM00903; Flavin_Reduct; 1.
DR   TIGRFAMs; TIGR02296; HpaC; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Flavoprotein; FMN; NAD; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..170
FT                   /note="4-hydroxyphenylacetate 3-monooxygenase reductase
FT                   component"
FT                   /id="PRO_0000085536"
SQ   SEQUENCE   170 AA;  18481 MW;  D6952B6942A3C217 CRC64;
     MQVDEQRLRF RDAMASLAAA VNIVTTAGHA GRCGITATAV CSVTDTPPSV MVCINANSAM
     NPVFQGNGRL CINVLNHEQE LMARHFAGMT GMAMEERFHQ PCWQNGPLGQ PVLNGALAGL
     EGEISEVQTI GTHLVYLVAI KNIILSQDGH GLIYFKRRFH PVRLEMEAPV