HPC2_SCHPO
ID HPC2_SCHPO Reviewed; 338 AA.
AC O43083;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Histone promoter control protein 2;
GN Name=hpc2; ORFNames=SPBC947.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Component of the HIR complex, which functions as a histone
CC chaperone that cooperates with cia1/asf1 to promote replication-
CC independent chromatin assembly. {ECO:0000250}.
CC -!- SUBUNIT: Component of the HIR complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the HPC2 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA17036.1; -; Genomic_DNA.
DR PIR; T40774; T40774.
DR RefSeq; NP_595268.1; NM_001021175.2.
DR AlphaFoldDB; O43083; -.
DR BioGRID; 277797; 478.
DR STRING; 4896.SPBC947.08c.1; -.
DR iPTMnet; O43083; -.
DR MaxQB; O43083; -.
DR PaxDb; O43083; -.
DR PRIDE; O43083; -.
DR EnsemblFungi; SPBC947.08c.1; SPBC947.08c.1:pep; SPBC947.08c.
DR GeneID; 2541284; -.
DR KEGG; spo:SPBC947.08c; -.
DR PomBase; SPBC947.08c; -.
DR VEuPathDB; FungiDB:SPBC947.08c; -.
DR eggNOG; ENOG502RG9A; Eukaryota.
DR HOGENOM; CLU_070878_0_0_1; -.
DR InParanoid; O43083; -.
DR OMA; RYADEYY; -.
DR PRO; PR:O43083; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IC:PomBase.
DR GO; GO:0000417; C:HIR complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IPI:PomBase.
DR InterPro; IPR014840; HRD.
DR Pfam; PF08729; HUN; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..338
FT /note="Histone promoter control protein 2"
FT /id="PRO_0000373989"
FT REGION 38..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 338 AA; 36629 MW; 94BCB44BDB52454F CRC64;
MSLLSGDQRI ICLEIPLQGK ENVHINFAKE VEKLYGPSVQ ENSKKNDLSD SADSEGESTH
VDEQQAANGA ADGTQTIKKK KRKRRYADEY YDRTDPFIDD AELYIEEKAA ATKDGFFVFS
GPLVAEGDTV KIERSKKTKK KKKTSLSNAT HPAPAVSAVV ASADASFDDS RDIESEDEQP
LRTLSIEMAA KNALKEAKRE NAKVPKDVSK KEAKTTKSKE KATKKTSSSV PKQSTGENTK
KAVKLETPLT STPPIPPLSE PKHSPATVNE HISPPSALTN PSTEELKPST SLPIDQGNAS
VVSKPTQQVS IVLSQNASLP VDEHQAEPEK SIPTSSIP
