ID   HPCC_ECOLX              Reviewed;         468 AA.
AC   P42269;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase;
DE            Short=CHMS dehydrogenase;
DE            EC=1.2.1.-;
GN   Name=hpcC;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C;
RX   PubMed=7737515; DOI=10.1016/0378-1119(95)00082-h;
RA   Roper D.I., Stringfellow J.M., Cooper R.A.;
RT   "Sequence of the hpcC and hpcG genes of the meta-fission homoprotocatechuic
RT   acid pathway of Escherichia coli C: nearly 40% amino-acid identity with the
RT   analogous enzymes of the catechol pathway.";
RL   Gene 156:47-51(1995).
CC   -!- FUNCTION: Transforms 5-carboxymethyl-2-hydroxy-muconic semialdehyde
CC       (CHMS) into 5-carboxymethyl-2-hydroxy-muconic acid (CHM).
CC   -!- PATHWAY: Aromatic compound metabolism; 4-hydroxyphenylacetate
CC       degradation; pyruvate and succinate semialdehyde from 4-
CC       hydroxyphenylacetate: step 3/7.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; X81322; CAA57102.1; -; Genomic_DNA.
DR   PIR; I41082; I41082.
DR   AlphaFoldDB; P42269; -.
DR   SMR; P42269; -.
DR   STRING; 585034.ECIAI1_4574; -.
DR   eggNOG; COG1012; Bacteria.
DR   SABIO-RK; P42269; -.
DR   UniPathway; UPA00208; UER00418.
DR   GO; GO:0018480; F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity; IEA:InterPro.
DR   GO; GO:1901023; P:4-hydroxyphenylacetate catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR011985; DH_HpaE.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   TIGRFAMs; TIGR02299; HpaE; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Oxidoreductase.
FT   CHAIN           1..468
FT                   /note="5-carboxymethyl-2-hydroxymuconate semialdehyde
FT                   dehydrogenase"
FT                   /id="PRO_0000056580"
FT   ACT_SITE        244
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        278
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   468 AA;  50827 MW;  93133200D2BFDB77 CRC64;
     MKKVNHWING KNVAGNDYFL TTNPATGEVL ADVASGGEAE INQAVATAKE AFPKWANLPM
     KERARLMRRL GDLIDQNVPE IAAMETADTG LPIHQTKNVL IPRASHNFEF FAEVCQQMNG
     KTYPVDDKML NYTLVQPVGV CALVSPWNVP FMTATWKVAP CLALGITAVL KMSELSPLTA
     DRLGELALEA GIPAGVLNVV QGYGATAGDA LVRHHDVRAV SFTGGTATGR NIMKNAGLKK
     YSMELGGKSP VLIFEDADIE RALDAALFTI FSINGERCTA GSRIFIQQSI YPEFVKFAER
     ANRVRVGDPT DPNTQVGALI SQQHWEKVSG YIRLGIEEGA TLLAGGPDKP SDLPAHLKGG
     NFLRPTVLAD VDNRMRVAQE EIFGPVACLL PFKDEAEALR LANDVEYGLA SYIWTQDVSK
     VLRLARGIEA GMVFVNTQFV RDLRHAFGGV KPRTGREGGG YSSKCSRK