3SUC1_NAJKA
ID 3SUC1_NAJKA Reviewed; 65 AA.
AC P82462;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2000, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Muscarinic toxin-like protein 1 {ECO:0000303|PubMed:11082188};
DE Short=MTLP-1 {ECO:0000303|PubMed:11082188};
OS Naja kaouthia (Monocled cobra) (Naja siamensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX NCBI_TaxID=8649;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Venom;
RX PubMed=11082188; DOI=10.1046/j.1432-1033.2000.01775.x;
RA Kukhtina V.V., Weise C., Muranova T.A., Starkov V.G., Franke P., Hucho F.,
RA Wnendt S., Gillen C., Tsetlin V.I., Utkin Y.N.;
RT "Muscarinic toxin-like proteins from cobra venom.";
RL Eur. J. Biochem. 267:6784-6789(2000).
CC -!- FUNCTION: Binds weakly to the muscarinic acetylcholine receptor (CHRM).
CC {ECO:0000269|PubMed:11082188}.
CC -!- SUBUNIT: Monomer. {ECO:0000305|PubMed:11082188}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11082188}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=7361; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11082188};
CC -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC residue stands at position 33 (Pro-31 in standard classification).
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. Type C muscarinic toxin sub-subfamily. {ECO:0000305}.
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DR AlphaFoldDB; P82462; -.
DR SMR; P82462; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR InterPro; IPR035076; Toxin/TOLIP.
DR Pfam; PF00087; Toxin_TOLIP; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond;
KW G-protein coupled acetylcholine receptor impairing toxin;
KW G-protein coupled receptor impairing toxin; Neurotoxin;
KW Postsynaptic neurotoxin; Secreted; Toxin.
FT CHAIN 1..65
FT /note="Muscarinic toxin-like protein 1"
FT /evidence="ECO:0000269|PubMed:11082188"
FT /id="PRO_0000093650"
FT DISULFID 3..24
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 17..42
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 46..57
FT /evidence="ECO:0000250|UniProtKB:P60301"
FT DISULFID 58..63
FT /evidence="ECO:0000250|UniProtKB:P60301"
SQ SEQUENCE 65 AA; 7366 MW; 1388A82AE2327351 CRC64;
LICVKEKFLF SETTETCPDG QNVCFNQAHL IYPGKYKRTR GCAATCPKLQ NRDVIFCCST
DKCNL