ID   HPCR_ECOLX              Reviewed;         148 AA.
AC   P62573; Q07095;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Homoprotocatechuate degradative operon repressor;
GN   Name=hpcR; Synonyms=hpaR;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C;
RX   PubMed=8384293; DOI=10.1007/bf00282806;
RA   Roper D.I., Fawcett T., Cooper R.A.;
RT   "The Escherichia coli C homoprotocatechuate degradative operon: hpc gene
RT   order, direction of transcription and control of expression.";
RL   Mol. Gen. Genet. 237:241-250(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W / ATCC 11105 / DSM 1900 / 113-3;
RX   PubMed=8550403; DOI=10.1128/jb.178.1.111-120.1996;
RA   Prieto M.A., Diaz E., Garcia J.L.;
RT   "Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway
RT   of Escherichia coli W: engineering a mobile aromatic degradative cluster.";
RL   J. Bacteriol. 178:111-120(1996).
CC   -!- FUNCTION: Repressor for the homoprotocatechuate catabolic pathway hpc
CC       operon.
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DR   EMBL; S56952; AAB25801.1; -; Genomic_DNA.
DR   EMBL; Z37980; CAA86039.1; -; Genomic_DNA.
DR   PIR; S30280; S30280.
DR   RefSeq; WP_000543916.1; NZ_WVVZ01000019.1.
DR   AlphaFoldDB; P62573; -.
DR   SMR; P62573; -.
DR   STRING; 585034.ECIAI1_4576; -.
DR   GeneID; 58389882; -.
DR   eggNOG; COG1846; Bacteria.
DR   OMA; KMQQLTA; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR012712; HpaR/FarR.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR02337; HpaR; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..148
FT                   /note="Homoprotocatechuate degradative operon repressor"
FT                   /id="PRO_0000054359"
FT   DOMAIN          2..134
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   148 AA;  17255 MW;  6F131D3A5300EB79 CRC64;
     MHDSLTIALL QAREAAMSYF RPIVKRHNLT EQQWRIVRIL AESPSMDFHD LAYRACILRP
     SLTGILTRME RDGLVLRLKP INDQRKLYIS LTKEGQALYN RAQTQIEEAY RQIEAQFTAE
     KMQQLTHLLE EFIALGNSRQ EDIPGDNE