HPCR_SHIFL
ID HPCR_SHIFL Reviewed; 148 AA.
AC P62574; Q07095;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Homoprotocatechuate degradative operon repressor;
GN Name=hpcR; Synonyms=hpaR; OrderedLocusNames=SF4385, S4655;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Repressor for the homoprotocatechuate catabolic pathway hpc
CC operon. {ECO:0000250}.
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DR EMBL; AE005674; AAN45801.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP19579.1; -; Genomic_DNA.
DR RefSeq; NP_710094.1; NC_004337.2.
DR RefSeq; WP_000543916.1; NZ_WPGW01000045.1.
DR AlphaFoldDB; P62574; -.
DR SMR; P62574; -.
DR STRING; 198214.SF4385; -.
DR EnsemblBacteria; AAN45801; AAN45801; SF4385.
DR EnsemblBacteria; AAP19579; AAP19579; S4655.
DR GeneID; 1025524; -.
DR GeneID; 58389882; -.
DR KEGG; sfl:SF4385; -.
DR KEGG; sfx:S4655; -.
DR PATRIC; fig|198214.7.peg.5169; -.
DR HOGENOM; CLU_083287_8_1_6; -.
DR OMA; KMQQLTA; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR012712; HpaR/FarR.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR PRINTS; PR00598; HTHMARR.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02337; HpaR; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..148
FT /note="Homoprotocatechuate degradative operon repressor"
FT /id="PRO_0000054360"
FT DOMAIN 2..134
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ SEQUENCE 148 AA; 17255 MW; 6F131D3A5300EB79 CRC64;
MHDSLTIALL QAREAAMSYF RPIVKRHNLT EQQWRIVRIL AESPSMDFHD LAYRACILRP
SLTGILTRME RDGLVLRLKP INDQRKLYIS LTKEGQALYN RAQTQIEEAY RQIEAQFTAE
KMQQLTHLLE EFIALGNSRQ EDIPGDNE
