HPDL_DICDI
ID HPDL_DICDI Reviewed; 494 AA.
AC Q557J8; Q86KI5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Uncharacterized 4-hydroxyphenylpyruvate dioxygenase-like protein;
DE EC=1.13.-.-;
GN Name=hpdl-1; ORFNames=DDB_G0273429;
GN and
GN Name=hpdl-2; ORFNames=DDB_G0273513;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May have dioxygenase activity. {ECO:0000305}.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000010; EAL70669.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70711.1; -; Genomic_DNA.
DR RefSeq; XP_644613.1; XM_639521.1.
DR RefSeq; XP_644637.1; XM_639545.1.
DR AlphaFoldDB; Q557J8; -.
DR SMR; Q557J8; -.
DR STRING; 44689.DDB0302487; -.
DR PaxDb; Q557J8; -.
DR EnsemblProtists; EAL70669; EAL70669; DDB_G0273429.
DR EnsemblProtists; EAL70711; EAL70711; DDB_G0273513.
DR GeneID; 8618977; -.
DR GeneID; 8619000; -.
DR KEGG; ddi:DDB_G0273429; -.
DR KEGG; ddi:DDB_G0273513; -.
DR dictyBase; DDB_G0273429; hpdl-1.
DR dictyBase; DDB_G0273513; hpdl-2.
DR eggNOG; KOG0638; Eukaryota.
DR HOGENOM; CLU_552566_0_0_1; -.
DR InParanoid; Q557J8; -.
DR OMA; DHIATCI; -.
DR PhylomeDB; Q557J8; -.
DR Reactome; R-DDI-8963684; Tyrosine catabolism.
DR PRO; PR:Q557J8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006572; P:tyrosine catabolic process; IBA:GO_Central.
DR CDD; cd07250; HPPD_C_like; 1.
DR CDD; cd08342; HPPD_N_like; 1.
DR Gene3D; 3.10.180.10; -; 2.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR11959; PTHR11959; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR SUPFAM; SSF54593; SSF54593; 1.
DR PROSITE; PS51819; VOC; 2.
PE 3: Inferred from homology;
KW Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome;
KW Repeat.
FT CHAIN 1..494
FT /note="Uncharacterized 4-hydroxyphenylpyruvate dioxygenase-
FT like protein"
FT /id="PRO_0000327997"
FT DOMAIN 18..174
FT /note="VOC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT DOMAIN 229..408
FT /note="VOC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT BINDING 232
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 349
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 460
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
SQ SEQUENCE 494 AA; 57087 MW; F34E3DC6C4BA6CEC CRC64;
MKNEKLKVDN HIHNNIQFID CLEFWVSNAK SFIKSFLQPM NFEVIGTRFN DERSRIQYLL
LNNVISRSNL QNQFQIENNS YIKPIQGNQF IKVTSSISPN DLDFHSKIQK HGDFIQNISF
YCNDINLAYN KSINNGAKSV QLPMKEYFKN CKDIVETAII ESPFKDLQHT FINRNITSFD
DNNNNNYDNN KEIFGNPLFL YPEFQEIKDK ELFKIEKEDS SSINGCTGSL DHIATCIKNG
EMNYFVEWYR KCLGFKLLSD KDSVATDESE NFENELILDK NFYVITKSDF KYTKKENIGL
KMAVLSNQPL NTSFHKTPPI QFVISEAIQG GEGQIEQFIH YFGGEGVQHL AFNSNNIFKA
VEIAKSQKLE FVYIPQSYYS KLDERLKHLF PNSIPKILKE NLMKFGILID SDAITNTNEN
NSNNNNNNDS QNNTEINQNI GYIKQIFTKY INDRPTMFFE LIERSNALGF GKGNIIALFE
SLEKESSGSQ LKSD
