HPDL_MOUSE
ID HPDL_MOUSE Reviewed; 371 AA.
AC Q8K248;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=4-hydroxyphenylpyruvate dioxygenase-like protein;
DE EC=1.13.-.-;
DE AltName: Full=Glyoxalase domain-containing protein 1;
GN Name=Hpdl; Synonyms=Gloxd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Cecum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have dioxygenase activity. {ECO:0000305}.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96IR7}.
CC -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
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DR EMBL; AK043902; BAC31697.1; -; mRNA.
DR EMBL; AK049217; BAC33615.1; -; mRNA.
DR EMBL; AK078929; BAC37467.1; -; mRNA.
DR EMBL; BC034099; AAH34099.1; -; mRNA.
DR CCDS; CCDS18519.1; -.
DR RefSeq; NP_666368.1; NM_146256.3.
DR AlphaFoldDB; Q8K248; -.
DR SMR; Q8K248; -.
DR BioGRID; 232436; 3.
DR STRING; 10090.ENSMUSP00000062327; -.
DR iPTMnet; Q8K248; -.
DR PhosphoSitePlus; Q8K248; -.
DR EPD; Q8K248; -.
DR jPOST; Q8K248; -.
DR MaxQB; Q8K248; -.
DR PaxDb; Q8K248; -.
DR PeptideAtlas; Q8K248; -.
DR PRIDE; Q8K248; -.
DR ProteomicsDB; 273165; -.
DR Antibodypedia; 32602; 45 antibodies from 18 providers.
DR Ensembl; ENSMUST00000055436; ENSMUSP00000062327; ENSMUSG00000043155.
DR GeneID; 242642; -.
DR KEGG; mmu:242642; -.
DR UCSC; uc008uho.1; mouse.
DR CTD; 84842; -.
DR MGI; MGI:2444646; Hpdl.
DR VEuPathDB; HostDB:ENSMUSG00000043155; -.
DR eggNOG; KOG0638; Eukaryota.
DR GeneTree; ENSGT00530000063474; -.
DR HOGENOM; CLU_034004_2_0_1; -.
DR InParanoid; Q8K248; -.
DR OMA; LYTPNIM; -.
DR OrthoDB; 1087836at2759; -.
DR PhylomeDB; Q8K248; -.
DR TreeFam; TF300622; -.
DR BioGRID-ORCS; 242642; 4 hits in 74 CRISPR screens.
DR PRO; PR:Q8K248; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8K248; protein.
DR Bgee; ENSMUSG00000043155; Expressed in morula and 61 other tissues.
DR Genevisible; Q8K248; MM.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
DR CDD; cd07250; HPPD_C_like; 1.
DR CDD; cd08342; HPPD_N_like; 1.
DR Gene3D; 3.10.180.10; -; 2.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR11959; PTHR11959; 1.
DR PIRSF; PIRSF009283; HPP_dOase; 1.
DR SUPFAM; SSF54593; SSF54593; 1.
DR PROSITE; PS51819; VOC; 2.
PE 2: Evidence at transcript level;
KW Dioxygenase; Iron; Metal-binding; Mitochondrion; Oxidoreductase;
KW Reference proteome; Repeat.
FT CHAIN 1..371
FT /note="4-hydroxyphenylpyruvate dioxygenase-like protein"
FT /id="PRO_0000271120"
FT DOMAIN 7..135
FT /note="VOC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT DOMAIN 160..328
FT /note="VOC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT BINDING 163
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 258
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 339
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
SQ SEQUENCE 371 AA; 39909 MW; 88D5D47644EC8F4E CRC64;
MTAPARRLCH IAFHVPAGQP LARDLHRVFG FQPLAVREAG GWRQLALRSG DAVFLVNEGT
GPQEPLYSLD PHHSVPSATN LCFDVEDVDG AARALAARGC IMPVPPTRVR DAQGTATYTV
LSSPAGNLSL TLLQRAGYRG SFLPGFRPLP CTPGPGWVSH VDHLTLACTS GSSPMLMRWF
HDCLGFHHLP LSPGEDPEMG LKVAAGSGRG GLRLTALQTP PNNTVPTLVL AESLPGLNSK
QDQVEQFLTR HGGPGLQHVG LYTPNIIDAS EGMAKAGCRL LTPPEAYYQQ PGKEEQILAA
GHKPGLLERQ GILLDGDKDE FLLQVFTKSL FAEDTFFLEL IQRQGATGFG QNNIRALWQS
VQEEAARAQG A
