ID   HPDL_RAT                Reviewed;         371 AA.
AC   Q5XIH9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase-like protein;
DE            EC=1.13.-.-;
DE   AltName: Full=Glyoxalase domain-containing protein 1;
GN   Name=Hpdl; Synonyms=Gloxd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May have dioxygenase activity. {ECO:0000305}.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96IR7}.
CC   -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
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DR   EMBL; BC083702; AAH83702.1; -; mRNA.
DR   RefSeq; NP_001014090.1; NM_001014068.1.
DR   AlphaFoldDB; Q5XIH9; -.
DR   SMR; Q5XIH9; -.
DR   STRING; 10116.ENSRNOP00000024393; -.
DR   PaxDb; Q5XIH9; -.
DR   Ensembl; ENSRNOT00000024393; ENSRNOP00000024393; ENSRNOG00000018143.
DR   GeneID; 313521; -.
DR   KEGG; rno:313521; -.
DR   UCSC; RGD:1310014; rat.
DR   CTD; 84842; -.
DR   RGD; 1310014; Hpdl.
DR   eggNOG; KOG0638; Eukaryota.
DR   GeneTree; ENSGT00530000063474; -.
DR   HOGENOM; CLU_034004_2_0_1; -.
DR   InParanoid; Q5XIH9; -.
DR   OMA; LYTPNIM; -.
DR   OrthoDB; 1087836at2759; -.
DR   PhylomeDB; Q5XIH9; -.
DR   TreeFam; TF300622; -.
DR   PRO; PR:Q5XIH9; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000018143; Expressed in heart and 16 other tissues.
DR   Genevisible; Q5XIH9; RN.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
DR   CDD; cd07250; HPPD_C_like; 1.
DR   CDD; cd08342; HPPD_N_like; 1.
DR   Gene3D; 3.10.180.10; -; 2.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR   InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR037523; VOC.
DR   PANTHER; PTHR11959; PTHR11959; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   2: Evidence at transcript level;
KW   Dioxygenase; Iron; Metal-binding; Mitochondrion; Oxidoreductase;
KW   Reference proteome; Repeat.
FT   CHAIN           1..371
FT                   /note="4-hydroxyphenylpyruvate dioxygenase-like protein"
FT                   /id="PRO_0000271121"
FT   DOMAIN          7..135
FT                   /note="VOC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   DOMAIN          160..328
FT                   /note="VOC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   BINDING         163
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         258
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         339
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   371 AA;  40032 MW;  C9C7D714F2DB1790 CRC64;
     MAAPARRLCH IAFHVPAGQP LARDLQRIFG FQPLAVREAG GWRQLALRSG DAVFLVNEGT
     GPREPLYGLD PHHSVPSATN LCFDVEDVDR AARALAARGC IMPVPPTRVR DAQGTATYTV
     VSSPAGNLSL TLLQRAGYRG SFLPGFRPLP CTPGPGWVSH VDHLTLACTS GSSPTLMRWF
     HNCLGFHHLP LSPGEDPELG LKVAVGSGRG GLRLTALQTL PNSTVPTLVL AESLPGLTSE
     QDQVEQFLTR HGGPGLQHVG LYTPNIIDAS EGMAKAGGRL LTPPEAYYQQ PGKEEQILAS
     GHKPSFLERQ GILLDGDKDE FLLQVFTKSL FDEDTFFLEL IERQGATGFG QNNIRALWQS
     VQEEAARAQG T